Genital herpes clinically underestimated because symptoms or sign occur only in some infection detected serologically. Prevalence of HSV subtypes in microbial etiology of Genital Ulcer Disease (GUD) in men, their association with clinical sign, complex of GUD and high-risk behavior were assessed. One hundred men with first episodes of genital ulcers were prospectively studied for serological evidence of syphilis (RPR and TPHA; T.pallidum IgM and IgG antibodies) and Polymerase Chain Reaction (PCR) proven chancroid and herpes. Demographic and epidemiological data were obtained in a standard interview. Positive syphilis serology observed in 11 cases, H. ducreyi detected in 65 cases and Herpes Simplex Virus in 13 cases. Among the PCR proven infections HSV type-2 detected in 7 cases, HSV type-1 in 4 cases and both HSV type-1 & 2 in 2 cases. Most of the HSV infections (92.3%) found as mixed infection with H. ducreyi. There was one PCR detected genital herpes case that was clinically undetermined. Among the PCR proven HSV infections clinical sign complex of genital herpes observed in one case, which had mixed microbial etiology. HSV infection was more prevalent in married than unmarried men (25.0% vs. 8.3%; P<0.05) and associated with early age promiscuous activity, multiple sexual partner, and sex with commercial sex workers and past infection with STDs. Presence of underdiagnosed HSV infection in men with GUD stress on the need for clinical suspicion of multiple infections. Patient with GUD should be carefully evaluated for HSV infection. Medicine Today 2010 Volume 22 Number 02 Page 55-61 DOI: http://dx.doi.org/10.3329/medtoday.v22i2.12430

Introduction: Psoriasis is a global burden of disease characterized by the presence of well circumscribed erythematous papule & plaque of various size & shape, covered by silvery scales. It not only hampers the quality of life but also hampers the sexual function. Men who have psoriasis may be more likely to have sexual problems, such as sexual apathy, orgasmic dysfunction, erectile dysfunction (ED), etc. Stress tends to be a triggering or aggravating factor in psoriasis. In addition, the disease itself can generate emotional stress because of its lesions. It is thought that chronic inflammation. Results in metabolic diseases and proinflammatory cytokines give rise to the development of atherogenesis. Pelvic arterial atherosclerosis is another cause of sexual dysfunction. This study was designed to determine the impact of moderate to severe psoriasis on quality of life and sexual dysfunction in male patients. Methods: This case control study was conducted in Department of Dermatology and Venereology, Dhaka Medical College Hospital, among the 100 patients. Group- A was cases (male married patients age between 24 years and 60 years with history of moderate to severe psoriasis) and group-B were control (male married patients age between 24 years and 60 years without psoriasis). Then variables were analyzed and compared. Data was processed and analyzed with the help of computer program SPSS and Microsoft excel. Quantitative data expressed as mean and standard deviation and qualitative data as frequency and percentage. Comparison was done by tabulation and graphical presentation in the form of tables, pie chart, graphs, bar diagrams, histogram & charts etc. Results: It was found that majority of the patients i.e. 46% were between 34-43 years, mean age was found to 41.7±11.3 years. No significant difference in age and other demographic profile was observed between groups. Prevalence of IHD (8.0%), stroke (14.0%), dyslipidaemia (54.0%), neuropathy (26.0%) and PVD (8.0%) were higher in case or psoriatic patients. On evaluation of Dermatology Life Quality Index (DLQI), majority of patients (54%) score was 6-10, followed by 24.0% had score 2-5 and 22.0% of patients had score 11-20 or very large effect on patient’s life. Prevalence of erectile dysfunction was 36.0%, prevalence of orgasmic dysfunction was 24.0%. On multivariate analysis which was done by ordinal logistic regression procedure. The attributes found to be positively associated with sexual dysfunction severity in the multivariate model were patient’s age, disable status, sedentary work, duration of illness, etc. Conclusion: Erectile dysfunction and orgasmic dysfunction are common in psoriatic male patients. There is association with other comorbidities. J Bangladesh Coll Phys Surg 2022; 40: 233-228