Microbubbles are small gas filled bubbles which has wide application in various industries. Stability of microbubble dispersion is of primary concern for the application of microbubbles in these fields. In this research, the stability of microbubble dispersion generated using CTAB surfactant is analysed by drainage mechanism. The stability is studied on the basis of half-life of microbubble dispersion. Microbubble dispersion gas fraction and rise velocity of microbubble is also calculated and the size of microbubble is estimated from the rise velocity of microbubble. Further, Silica nanoparticles are added in the surfactants to study their effect on the stability of microbubble dispersion. The observed results clearly indicates that the stability of microbubble dispersion is significantly affected by the surfactant concentration and the weight of silica nanoparticle in the liquid. Similar results were observed for rise velocity and bubble size. The present work may be beneficial for the application of microbubble in various chemical and biochemical industries and scientific community.