Angiomyolipoma is a benign neoplasm composed of variable admixture of blood vessels, smooth muscle cells and adipose tissue. Cervical angiomyolipoma are extremely rare and to the best of our knowledge only five cases of angiomyolipoma in cervix have been reported in the literature till date. Authors are presenting a case of angiomyolipoma arising from the uterine cervix. 43 years old female presented with mass descending per vagina for 6 months. This case had no association with tuberous sclerosis. Microscopic examination showed an ill-defined polypoidal, non-encapsulated lesion covered by keratinized stratified epithelium. The lesion is made up of three components, predominantly by fascicles of spindle shaped cells, varying sized blood vessels and multiple foci of mature adipocytes with no evidence of atypia or increased mitotic activity. Smooth muscle component showed strong immunoreactivity to SMA and absence of elastic fibres in the blood vessels were confirmed by histochemistry. Non-vascular smooth muscle cells were negative for HMB-45 in contrast to renal and other extra-renal angiomyolipoma in which HMB-45 immunoreactivity in seen in these cells. To conclude, the differential diagnosis of lower abdominal mass and dysfunctional uterine bleeding should include the angiomyolipoma, even though the uterine cervix is an extremely rare location where they occur.

Background: Helicobacter pylori (H. pylori) is one of the major cause of gastrointestinal diseases. It is classified as class-I carcinogen & thus Its important to study the histological changes in H. pylori gastritis. Aim: To evaluate associated histological features and prevalence of H. pylori associated gastritis by histopathological method. Methods and Material: Biopsies from 75 patients with various upper gastrointestinal symptoms were studied. Study period was from August 2016 to August 2018. Each biopsy was stained with Haematoxylin & Eosin (H&E) & Warthin Starry silver stain. The slides were examined for H. pylori & various histological features. Results: H. pylori infection was high in the fourth decade with male predominance. 47/75 (62.6%) cases were H. pylori positive. Among H. pylori positive cases neutrophilia activity, mononuclear infiltrate, atrophy & intestinal metaplasia was seen in 93.6%, 100%, 14.9% & 2.2% cases respectively. Conclusion: Histopathological evaluation is the gold standard for diagnosing H. pylori infection. Furthermore, large scale studies are required to evaluate H. pylori associated gastritis to prevent morbidity & mortality.

Serum ferritin concentrations have been documented to give an accurate indication of the amount of storage iron not only in healthy individuals but also in cases of iron deficiency or iron over load. A low serum ferritin is highly indicative of deficient iron stores. Values less than 15ng/ml are indicative of negative iron balance or decreased stores. In cases of anemia of chronic diseases, serum ferritin levels are increased as serum ferritin is an acute phase reactant. Thus, in patients of anemia of chronic diseases with concomitant iron deficiency, serum ferritin may not be below 15ng/ml and serum ferritin may not give a true picture of deficiency in these patients. In the present study, we determined the role of serum ferritin as an indicator of body iron stores along with the cut-off value for serum ferritin to detect hypoferremia in patients of anemia of chronic diseases.

Abdominal tuberculosis and colon carcinomas are commonly seen in patients worldwide. However co-existing gastrointestinal tuberculosis and adenocarcinoma in the same site is unusual and is a rare entity. We here in report an interesting case of tuberculosis and adenocarcinoma occurring concomitantly in the colon, along with metastasis and caseating tuberculosis in mesenteric lymph nodes in a 73-years-old female presenting with pain in abdomen, vomiting and nausea.

Introduction:Chorangioma is a rare primary vascular tumour of placenta with an incidence of about 1% in carefully examined term placenta. Chorangiomas in the past have been described as hemangiomas. Chorangioma is a benign, vascular, non-trophoblastic tumor of plancenta that is potentially threatening and can lead to hazardous feto-maternal catastrophy. Objectives: To analyse clinicopathological characteristics, diagnosis, differential diagnoses, treatment, and prognoses of placental chorioangioma (PCA). Results: Mean age of the patients was 38 years. 2 patients were below 30 years and 2 were above 30 years. Only 1 patient was primigravida, rest 3 were multigravida. Mean gestational age was 31.8 weeks. 3 out of 4 cases were term gestations. Out of 4 patients, 3 had an emergency LSCS and 1 had normal labor. 1 out of the 4 patients delivered a dead fetus. Grossly, all the specimens werecomplete placenta. All lesions were extraplacental, solitary and all were >5cm. The mean tumor size was 7.3 cm (range: 6-8.5cm). All the tumowere nodular, well circumscribed, solid masses. On cut-section, lesions were reddish-brown to tan-off-white, solid, firm, hemorrhagic masses as depicted in the pictures. Microscopically, the lesions were composed of network of proliferating capillaries lined by benign endothelium in enlarged villi covered by trophoblastic epithelium. Focal hyalinized areas were seen in one of the cases as depicted in the pictures. Conclusion: Giant chorangiomas are relatively rare, however, their diagnosis and management pose a big challenge owing to serious antenatal feto-maternal complications they lead to. Careful radiological and histopathological examination are thus of utmost importance.