Introduction: Breast carcinoma is the second leading cause of cancer related mortality in females around the world. Ultrasound plays a key role in differentiating cystic and solid lesions and is a convenient and non-invasive diagnostic tool to differentiate between benign and malignant lesions. Objectives: The aim of this study is to evaluate the diagnostic accuracy of ultrasound in palpable breast lesions. Methodology: A prospective cross-sectional study was carried out in patients with palpable breast lesions who presented in Department of radio diagnosis and imaging of Nobel Medical collegefor a period of one-year from February 2019- January 2020 using ultrasound. A total of 60 patientswereevaluated in the study. Sensitivity, specificity, positive predictive value, negative predictive value and accuracy were calculated. Results: Out of 60 patients evaluated, ultrasound showed 46 (76.7%) cases to be benign and 14 (23.3%) cases to be malignant. FNAC revealed benign disease in 47 (78.3%) patients and malignant disease in 13 (21.7%) patients. The most common benign lesion was fibroadenoma. We found nearly 91.7% of the malignant lesions had spiculated margins and microcalcification. The sensitivity of ultrasound was 95.74% and specificity 92.3% with diagnostic accuracy 95%. Conclusion: Ultrasound is a convenient and non-invasive diagnostic tool with good sensitivity, specificity, positive predictive value, negative predictive value and accuracy in palpable breast lesions.

Background: Cervical cancer is a leading health problem among women all over the world with significant mortality and morbidity in developing countries like Nepal. Pap smear is an effective and cost efficient diagnostic technique for cervical lesions. This study aims at histopathological correlation of cervical Pap smears. Materials and Methods: A cross sectional study was conducted from January 2020 to January 2022 in Pathology department of Nobel Medical College Teaching Hospital (NMCTH). 119 cases of cervical Pap smear were reported using the Bethesda system and correlated with histopathological examination findings for various epithelial cell abnormalities. Analysis was done using SPSS software version 20. Results: Out of 5110 smears examined, 119 were positive for epithelial cell abnormalities. Cellular abnormality was commonly seen between 31-60 years of age. Low grade Squamous Intraepithelial Lesion was the commonest lesion found. Pap smear findings had good concordance rates with histopathological findings for individual lesions. The overall sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of Pap smear were 84%, 23.1%, 89.9%, 15% and 77.3% respectively. Conclusion: Pap smear has a good diagnostic accuracy, sensitivity and positive predictive value in diagnosing cervical lesions in comparison to histopathological examination

Background: Determination of sex is an important parameter other than age, race and stature during forensic identification and crime scene investigation. Females tend to have finer and denser ridges on their fingertips than males. Present study aims at differentiating gender from fingerprint ridge density. Material and Methods: This is a cross sectional study conducted from March 2022 to March 2023 in Nobel Medical College Teaching Hospital, Nepal. Seven hundred fingerprints samples (350 males and 350 females), from 70 Nepalese medical students were collected and analyzed for gender differences. Comparative analysis was done using Student’s t-test (p<0.05). Likelihood ratio and posterior probability using Baye’s theorem were calculated to interpret the possibility of gender differentiation from various fingerprint ridge densities. Results: Students t-test revealed significant difference (p < 0.001) between the fingerprint ridge density of male and female (t= -16.733). The results showed ridge density <14/25mm2and >15/25mm2 are “more likely than not” from males and females respectively. Posterior probability using Baye’s theorem further revealed ridge density <13/25mm2 (C/C1=5.75,P=0.86) and >16/25mm2 (C1/C=4.29, P1=0.84) have higher probability of originating from males and females respectively. No any male and female had ridge density >16/25mm2 and <13/25mm2 respectively. Conclusion: The study revealsstatistically significantlygreater fingerprint ridge densities in female than in male Nepalese medical students.