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Background: Malocclusion, one the most important oral health problem among children and young adults, leads to social stigma and psychological disorders. Early orthodontic treatment for children appears to be one of the efficient methods to prevent these consequences. Materials and Methods: This cross-sectional study, which was conducted in Shiraz, city of Iran, comprised 1600 primary school children aged 7 and 8 years old from 16 schools in the 4 districts of Shiraz. Self-administered questionnaires, giving scores to parental knowledge and attitude towards early orthodontic treatment, were designed and distributed to the children to deliver them to their parents. The maximum possible mean score for both knowledge and attitude questions were. Results: Out of 1600, 1026 (64%) questionnaires were returned. The analysis revealed the mean score of parental knowledge and attitude as 0.78 and 0.38 respectively. The mean score of participants from high social class was significantly higher in the knowledge and attitude sections (P value < 0.001). Highly educated parents presented an appreciably greater level of attitude score (mean score: 0.43, P value < 0.001). A remarkable correlation of parental former orthodontic treatment with a routine and problem-based visit of a dentist was observed [odds ratio (OR): 3.1, 95% confidence interval (CI): 2.1 to 4.4] and (OR: 3.1, 95% CI: 2.2 to 4.4) in order. Conclusions: This study showed significant effect of higher social class on the parents' knowledge and attitude and also beneficial impact of higher educational level on parents' attitude. The parents, who were former orthodontic patient, were more concerned about their children's dentofacial health.

Stroke, a multifactorial disease, has distinct pathophysiologic mechanisms, among which inflammation plays a pivotal role. Various types of inflammatory cells, substances, and molecules emerge in the ischemic stroke. Neutrophils, Tcell subtypes, macrophages, microglial cells, dendritic cell, mast cells, asrocytes, as influential cell,  tumor necrosis factor_α, interleukin-17, interleukin-10, as released substances, and  vascular cell adhesion molecule-1 (VCAM-1), leukocyte very late antigen-4 (VLA-4), and glial fibrillary acidic protein (GFAP), as cellular adhesion molecules. Lymphocytes' invasion to the ischemic brain tissue occurs as the result of VLA-4  ̶ VCAM-1 interaction. Regarding Tcell subtypes, CD4+ cells have known detrimental effects in the ischemic area, while natural killer T cells (NKT cells) and γδ T cells have minor importance in the early stage of ischemia. While some studies proved the cerebroprotective impact of T regulatory cells, others refuted this by presenting a prominent harmful role of them. Bcells have important protective function by releasing IL-10. Neutrophils along with microglial cell, appearing as the first inflammatory cell in the ischemic tissue, and also macrophages deteriorate ischemia. Mast cells and dendritic cells are of great value in stroke progression. The resting astrocytes are neuroprotective, whereas the activated ones present detrimental function in the ischemic region by expression of GFAP. Hence, stroke consequences occur as the result of systemic inflammatory response. The more activation of this system, the poorer neurological outcomes would be observed. As expected, anti-inflammatory interventions in the experimental stroke in animals, have revealed successful results as less infarct size and attenuated neurological damages.

Objective: To investigate about frequency of different subtypes of stroke in south of IranMethods: This  is a retrospective, single-center study  conducted at Namazi Hospital, Shiraz, south of Iran. Age, sex, length of hospitalization and  mortality  of  stroke patients were recorded by reviewing hospital medical records.Results: 16 351 patients (53.6% male, 46.4%female) were recruited.  Ischemic stroke (10750 patients, 65.7%), intracerebral hemorrhage(3282 patients,20.1%) and subarachnoid hemorrhage(1057 patients,6.5%)  were the most common subtypes of stroke, respectively. In 1262 patients (7.7%) the stroke subtype could not been specified. Ischemic stroke and intracerebral hemorrhage were more common in men but subarachnoid hemorrhage was more common in women. Subarachnoid hemorrhage occurred significantly in younger patients. Mortality was significantly higher in intracerebral hemorrhage. Hospital stay was significantly longer in subarachnoid hemorrhage group.Conclusion: the distribution of the different  subtypes of stroke in Iran is similar to Caucasians.

Background: Axial load on thoracolumbar junction, both mechanical and anatomical transitional zone, causes the compression and flexion of the spine, and consequently thoracolumbar burst fractures. Objective: This study aimed to investigate the effect and prognostic factors associated with the postural and instrumented reduction on the restoration of vertebral height and kyphosis angle in thoracolumbar burst fractures. Material and Methods: This retrospective cohort study was conducted on 41 patients with A3, A4, and B type thoracolumbar burst fractures, subjected to postural and instrumented reduction for the restoration of vertebral height and kyphosis angle. The magnitude and correction of kyphotic deformity and percentage of vertebral body collapse were measured before and after postural reduction, and after instrumental insertion to find if they were affected by fracture type and level, time-to-surgery, and use of pedicular screws at the fractured level. Results: Postural and instrumental reduction significantly improved both the kyphosis angle and the percentage of vertebral body height, regardless of AO types (p.value <0.001 and p.value <0.001, respectively). AO type A3, and A4 comparing to type B, has better restoration of kyphosis angle by postural (p-value=0.013, p-value=0.007, respectively) and instrumental reduction. (p-value=0.006, p-value=0.014, respectively). Evaluation of time to surgery showed that performing operation during the first four days would result in better correction of kyphosis angle (p-value 0.015). Conclusion: AO type A3, and A4, time to surgery before 4 days, and fracture level at L2 were favorable prognostic factors to better restoration of kyphosis angle using both postural and instrumented reduction.