This paper describes the creation of a rationalization sequence for working with simulation models, and its subsequent verification in the redesigning of lighting in cooperation with digital enterprise tools. The rationalization sequence consists of 11 sequences, whose accuracy is subsequently verified on a practical example of the redesign of an assembly room of a production hall in the simulation tool Dialux Evo. In conjunction with the proposed procedure, a redesign of the assembly workplace located in the production hall for daylighting, artificial, and mixed lighting was created. The conclusion of the paper provides an overview of the benefits gained from the application of the work environment rationalization procedure.