Background: To analyze the cost ratio and percentage cost variations in different brands of the commonly prescribed anti-epileptic drugs available in Indian pharmaceutical market.Methods: The maximum and minimum price of each brand of the drug given in INR was noted by using CIMS January to April 2018 edition and drug today April to June 2018 Vol-1. The cost ratio and the percentage cost variation for individual drug brands was calculated. The cost of one bottle in case of 100ml syrup and 10 tablets/capsules was calculated in case of oral drugs and the cost of one 1 vial or ampoule was noted in case of injectable drugs. At last the cost ratio and percentage cost variation of various brands was compared.Results: After calculation of cost ratio and percentage cost variation for each brand of anti-epileptic drug tablet clonazepam (2mg) shows highest cost ratio and percentage cost variation as: 10.41 and 941.66, carbamazepine (200mg SR tablet) shows lowest cost ratio and percentage cost variation as: 1.09 and 9.32.Conclusions: Epilepsy is the most common neurological disorder and Epileptic drugs are to be prescribed for prolonged period. If a costly brand is prescribed, the patients have to pay more money unnecessarily for their treatment. There is a wide difference in the cost of different brands of anti-epileptic drugs available in India. The clinicians prescribing these drugs should be aware of these variations in cost to reduce the cost of drug therapy.

BACKGROUND Amlodipine is a calcium channel blocker widely used as antihypertensive drug. It has main action on vascular smooth muscle, cause vasodilatation. Erythematous rash and peripheral neuropathy are very rare and uncommon adverse effects of amlodipine. A 70 years old patient has shown these type of adverse effect by the use of amlodipine for the treatment of hypertension.