The world livestock industry emerging by defeating all its limits and challenges in the course of mass production. Many pathogenic disease outbreaks restrict the scope for a better management practice rather to go for a better medication. Epizootic hemorrhagic disease virus (EHDV) can be considered as the major threat in the livestock industry causing severe loss in the production as well as revenue generation. Several EHDV outbreak reports have been recorded along with immense research to understand the molecular mechanism of viral replication along with the structure, while a better management practice can strongly expect to prevent the subsequent infection. Several important characters directly or indirectly influence the EHDV outbreaks in different locations. The continuous disease occurrence and its significant impact on the livestock industry impose the conception of the management practice to prevent further consequences of EHDV infection.