R abies is an acute animal disease which can communicate from animal to human. When it has shown clinical symptoms, rabies cases always end in death, both in animals or humans (Ditkeswan, 2015). The World Health Organization (WHO) stated that 99% of rabies cases caused by dog bites (WHO, 2018a). WHO also estimated that deaths caused by rabies reach 59,000 cases each year globally with 95% of cases occurring in Africa and Asia (WHO, 2018b). Historically, Bali Province of Indonesia is free from rabies, until the first confirmed case of both animals and humans rabies in Semenanjung Bukit, Badung District (Putra, 2011). Semenanjung Bukit is relatively a localized area so we have a good hope that rabies can be controlled rapidly. Although the coordination method of control and eradication of rabies in Bali have been applied using cross-sectoral approach, bothin the level of local and center, the spread of the disease cannot be controlled. It resulted the spread of disease in all areas of Bali Province in June 2010 (Putra et al., 2009). Then, it resulted people's anxiety and threat to the development of Bali tourism (Putra, 2011). Moreover, the data from the Ministry of Health showed that 54.76% of cases of rabies animal bites in Indonesia in 2011-2017 occurred in Bali Province (Kemenkes, 2018). Rabies is a disease that can be controlled by the surveillance system through continuous disease detection to identify the infection of rabies in animals (Ditkeswan, 2015). Spatial analysis is one of methods for analyzing the surveillance data that is useful for identifying and analyzing patterns of disease in an area. The analysis produced a visual aid in research Article Abstract | Bali Province contracted rabies at the end of 2008. The first case of rabies in the province occurred in Badung District and then spread to other areas until all areas of the province were infected with rabies.. The study aimed to analyze the pattern of spatial occurrence of rabies cases in dogs in Bali Province. Data of dog rabies cases was obtained from the surveillance conducted by the Denpasar Veterinary Disease Investigation Center in 2012-2018. The data analysis was carried out using autocorrelation of Morans Index. The results show that rabies cases in a region affected adjacent areas. Spatial correlation produces hotspot (high case areas surrounded by low case areas), coldspots (low case areas surrounded by high case areas), quadrant I (high case areas surrounded by high case areas), and quadrant III (low case area surrounded by low case areas) areas. Nine sub-districts are recurrent hotspot areas and the potential of the areas as source of rabies spread need to be observed. Otherwise, 19 sub-districts are known to be recurrent coldspot areas that have a high potential as area susceptible to rabies transmission. Areas included in quadrant I are dominated by sub-districts in Karangasem, Buleleng, Jembrana, and Bangli District. Sub-district included quadrant III increased subdistricts in number over the past two years, showing progress in imp...