This review confirms the lack of efficacy of OTC cough and cold products in children and reaffirms that although the overall incidence of related serious adverse events is low, such events continue to occur. The conclusions in this paper support a recommendation that OTC cough and cold medications should not be given to infants and very young children. Furthermore, additional research is needed to evaluate the safety and efficacy of these medicines in the broader pediatric population.

The physical principle that governs how ships are moored to a port has changed little over the years. Nevertheless, in recent decades, there have been developments in maritime transport towards increased vessel dimensions and operations in specialist terminals. These trends mean that offshore ports and mooring systems have to face more challenging conditions in terms of the waves, wind and drift current. At the same time, pier side port loading and unloading systems place demands on the mooring system, which must immobilise ships better. In this situation, the mooring system's own equipment, such as lines, deck fittings and mooring winches, must also evolve to work alongside new port devices. It is also necessary to point out that changes in mooring will take place in subsequent years. These innovations in attaching the ship to the pier will be highlighted here as they mark a significant change in mooring and pier components.

x the mean (CV%) of C max , C min , and AUC s were 193-228 pg/mL (32.9-46.4%), 17.6-22.8 ng/mL (43.7-64.4%), and 1680-1820 pgÁh/mL (28.7-36.6%), respectively. The elimination t 1/2 was 6.84-8.82 h after repeat dosing. No steadystate accumulation was observed. Plasma concentrations of TP were below the limit of quantification (100 pg/mL) at all time points measured. Conclusion: TPIP was well tolerated at the doses tested, and dose titration improved tolerability. Treprostinil pharmacokinetics were linear and supportive of a QD treatment regimen. These results support further development of TPIP in patients with PAH and PH-ILD.

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