The most frequent extra-nodal site of lymphoma is gastric lymphoma. The bulk of such lesions are extra nodal marginal zone B mucosal cell lymphoma correlated with lymphoid tissue (MALT) type or diffuse lymphoma of large B cells. We are reporting a case of diffuse major B-Cellular gastric lymphoma, which at first showed indigestion, abdominal heaviness, nausea and widespread weakness with 3-4 months of weight loss. In the antropyloric region and distal portion of lesser curvature of stomach suggestive of aetiology of cancer, the CT abdomen shows circumferential wall thickening. DLBCL has been confirmed by HPE and IHC. The neoplasm entered serosa and was found to have adherence to the pancreatic capsule in stage IIE of gastric lymphoma. Following the staging, treatment with an R-CHOP regimen (rituximab, cyclophosphamide, oncovin (vincristine), hydroxydaunorubicin, and prednisone) was done.

Introduction: Zn supplementation improved glutathione peroxidase enzyme activity and decreased malondialdehyde and nitric oxide levels in diabetic rats, revealing Zn's defensive effect against oxidative stress in type 2 diabetes. The investigators have discovered that consuming Zn increased liver function and protected pancreatic tissue from damage caused by diabetes. Since Zn also prevents chronic hyperglycemia, it helps to minimize oxidative stress caused by type 2 diabetes. Diabetes mellitus (DM) is a global health problem that affects more than 3 million people worldwide (16% of population). Chronic hyperglycemia causes oxidative stress in diabetic patients by the development of free radicals (oxidants) and lowering the antioxidant protection mechanism. Aim: Glycaemic Regulation with Zinc Combination in Type 2 Diabetes Mellitus. Materials and Methods: Faculty of Medicine and Diabetic Opd, Datta Meghe Mediсаl Соllege and Shаlinitаi Meghe Hоsрitаl аnd Reseаrсh Сenter, Nаgрur in соllаbоrаtion with Dаttа Meghe Institute оf Mediсаl Sсienсes Deemed to be University, Sаwаngi, Wаrdhа, Mаhаrаshtrа. Results: The mean Zn level was 12.213±2.342in all participants and 9.121±1.782 in the control group, whereas it was significantly low (9.121±1.782) in the diabetic group, and there was statistically significant difference in Zn levels between the controls and the diabetic group (P < 0.001).FBS, HbA1C, serum Zinc mean effects between control and patients showed statistically significant differences in type 2 diabetes mellitus (P <0.0001). Conclusion: Our findings show that people with diabetes have lower levels of Zn than healthy people. The cause and effect of the association between very low levels of Zn and the progression of diabetes, or diabetes that causes Zn deficiency, is still unknown. Low levels of Zn are associated with poor glycemic control, and poor glycemic control is a good indication of Zn deficiency, as there was a negative association between serum Zn and FBS and HBA1C. If diabetic patients have low glycemic regulation, a long history of diabetes, obesity, or are over the age of 50, we look to assess their levels in Zn so that Zn alternative treatment can begin to release oxidative stress in this high-risk group.

Introduction: Diabetes mellitus (DM) is a metabolic disorder that is greatly exacerbated by a complete lack of insulin or insulin resistance. The pancreas is a multicellular organ, the exocrine half accounting for 84% of its volume and the endocrine half accounting for only 2%. Since these two parts of the world have a close relationship with structure and function, the disruption of one can affect the other. Hemoglobin A1C (HbA1c) represents the glycemic status of the patient over the previous three months. Evidence suggests that pancreatic endocrine hormones, especially insulin, affect pancreatic exocrine function. Insulin has a detrimental effect on exocrine acinar cells. Exocrine acinar cells attached to it contain a variety of enzymes, including amylase and lipase, which help digest certain food particles. Aim: Study of serum pancreatic amylase and lipase enzyme in patients with type 2 diabetes. Materials and Methods: This cross sectional study was done in the Department of Biochemistry, dept. of medicine and Diabetic OPD, Datta Meghe Medical College and Shalinitai Meghe Hospital and Research Centre, Nagpur. For this study 40 diagnosed type 2 diabetic patients of both sexes with age ranging 35-60 years were selected as study group. Results: FBS, HbA1C, serum pancreatic amylase, and lipase mean effects between control and patients showed statistically significant differences in type 2 diabetes mellitus (P <0.0001). Conclusion: We concluded that pancreatic amylase and lipase function are impaired in type 2 patients with diabetes, and this observation is particularly important in type 2 diabetes. It has been suggested that the analysis of pancreatic enzymes in diabetic patients may be a useful parameter in determining the progression of the disease.

Introduction: Cigarette smoke increases the risk of cardiovascular disease, such as coronary heart disease and peripheral vascular disease. Atherosclerosis, myocardial infarction, and stroke are also examples of ischaemic heart disease. Cigarette smoke contains more than 4,000 substances that have a negative or minimal effect on human health, including free radicals, nicotine, and the most important carbon monoxide in the pharmacy. Tobacco smoke kills 6 million people a year, many from lung cancer, chronic obstructive pulmonary disease (COPD), and cardiovascular disease (CVD). When opposed to never-smokers, smokers lose 10–15 years of life on average, and they begin to develop tobacco-related disorders such as coronary disease. Aim: Study of Cigarette Smoking on Haematological parameters and Lipid Profile in Vidharbha Region Material and Method: 25 subjects were smokers and 25 subjects were non-smokers. Patients went directly to the Observed Treatment Short-course focus in the Dept. of Medicine and Dept. of Respiratory, Datta Meghe Medical College and Shalinitai Meghe Hospital and Research Center. Result: Patients who were non-smokers and smokers were compared. Total cholesterol, triglycerides, LDL, and VLDL are statistically higher in smokers than non-smokers, but the same is true for HDL-cholesterol. Smokers had slightly lower HDL cholesterol than non-smokers. Conclusion: The smokers in this sample had dyslipidaemia as well as a large rise in haemoglobin and haematocrit. The RBC count rises as the rate of smoking rises, as it does in heavy smokers, and the altered lipid profile worsens. This dyslipidaemia in smokers can expose the vascular endothelium to potentially atherogenic lipoproteins, placing smokers at higher risk of developing atherosclerotic plaques and heart disease. As a result, quitting smoking early can alter these processes, which may prevent any major health risks.

Background: Chronic kidney disease (CKD) is a pathophysiologic process characterised by a decrease in nephron number and function, which often leads to end-stage renal disease (ESRD). Serum plasma cystatin C is a new test for determining kidney function. Its accuracy in determining the efficacy of haemodialysis in patients with end-stage renal disease has yet to be determined. Serum cystatin C, which is formed at a constant rate by all nucleated cells and filtered freely by the glomerulus, is neither secreted nor reabsorbed, and is unaffected by non-renal influences. Materials and Methods: This study was a comparative study, conducted in the nephrology Department at DMMC & SMHRC, Nagpur in collaboration with ABVRH and JNMC Wardha, Sawangi (Meghe) during September 2020 to March 2021. Total 25 patient (End stage renal disease) included for the present study, the age group 30-60 years with 17 male patients and 08 female patients. Result: Serum creatinine concentration in the before hemodialysis with 8.72±3.00 and for the after hemodialysis 3.20±1.18(P < 0.0001). The serum cystatin C concentration in the before hemodialysis 5.50±2.09 and for the after hemodialysis 8.7±1.75(P < 0.0001). the process of hemodialysis leads to a significantly low in a serum creatinine concentration as compared to before hemodialysis. The serum cystatin C concentration significantly increase in the after hemodialysis patient as compared to before hemodialysis. Conclusion: Hemodialysis adequacy cannot be determined using serum cystatin C. It does, however, serve as a surrogate marker of dialysis inadequacy, particularly when low flux membranes are used. Routine examination of serum cystatin C in hemodialysis patients will help in the monitoring of the patient's overall clinical condition.