Quinoline is an important heterocyclic scaffold which is found in a variety of natural compounds (cinchona alkaloids) and therapeutically active drugs with various biological functions. Because of its varied chemical and pharmacological characteristics, quinoline and its derivatives have long drawn the attention of both synthetic and biological chemists. A newer class of quinoline-isatin tethered 1,2,3-triazole conjugates was synthesized in this context, using copper-promoted click chemistry with various organic systems. Ten derivatives of 1,2,3-triazole-tethered 8-hydroxyquinoline and 5-chloro-8-hydroxyquinoline derivatives of isatin were synthesized and well characterized by using analytical techniques such as mass spectrometry, IR, 1H NMR and 13C NMR spectroscopy.