Grading system uses A, B, C, or E to show the evidence level that supports each recommendation.• A -Clear evidence from well-conducted, generalizable randomized controlled trials that are adequately powered.• B -Supportive evidence from well-conducted cohort studies.

Aim: To evaluate the efficacy and safety of biphasic insulin aspart during first 2 to 8 days of hospital admission of patients with type 2 diabetes (T2DM) for non-glycemia related medical ailments. Methods: An open-label, non-randomized, observational, single-center study in patients with T2DM aged between 18 and 70 years at a tertiary multispecialty hospital in India. T2DM patients with capillary blood glucose (BG) between 70 mg/dl to 400 mg/dl at admission, requiring subcutaneous biphasic insulin aspart were included in this study. Insulin dosage was individualized as per the clinician’s judgement considering the clinical status, HbA1c and other co-morbidities. The primary endpoint was mean capillary BG levels at fasting, prelunch, predinner and at midnight during day 2 to day 8 of hospital stay. Secondary endpoints were frequency and severity of hypoglycemic episodes. Appropriate statistics were applied at 2-tailed p ≤0.significance. Results: Total 2T2DM patients were included in this study. Median age was 57 years, 66.3% male and 33.7% female. Mean duration of T2DM was 9.9 years, HbA1c 7.3%, BMI 25.9 kg/m2 and hospital stay 8.9 days. The mean (SD) BG at admission was 208.5 (82.9) mg/dL and after usage of Biphasic Insulin Aspart 188.2 (45.3) mg/dL. Mean capillary BG levels at fasting, prelunch, predinner, and at midnight were 166.9 (46.7) mg/dL, 201.0 (58.8) mg/dL, 203.9 (60.1) mg/dL, and 179.0 (48.7) mg/dL respectively. BG readings that met the target BG range (140-180 mg/dL) levels were 34.6%. During the study 5.9% of patient’s experienced hypoglycemic event of which 2% were severe requiring intravenous dextrose and 3.9% were mild. There was a significant difference in BG reduction correlating with BMI, HbA1c (p =0.05). Conclusions: Treatment with biphasic insulin aspart is observed to be effective in achieving optimal BG levels, is well-tolerated with low hypoglycemic events in patients admitted in hospital for non-glycemia related medical ailments. Disclosure R.S. Erukulapati: None. A. Yerramilli: None. V. Kancherla: None. G.S. Sreelalitha: None. A. Poojari: None. F.Z. Khan: None. K. Chappidi: None.

Aim: Diet and knowledge of it plays a crucial role in the management of diabetes. The purpose of the study was to survey diabetes patients’ awareness of the basic ingredients of diet and their insights into the facts and fads of their daily dietary constituents. Methods: An objective qualitative questionnaire-based assessment was performed among outpatient diabetes patients who visited Apollo Sugar diabetes care center in a metropolitan city, India. The questionnaire was answered by patients in a simple ’Yes’ or ’No’ format relevant to their awareness of various foods. The questions were about the protein, carbohydrate, fat constitution, quantity that could be consumed, and myths surrounding various food products they come across in their daily routine. Patients’ perception of diet was categorized into ’correct’ and ’incorrect’ depending on their response to each question mentioned in a 10-point questionnaire. A score of ’1’ was given for each ’correct’ answer and ’0’ for an ’incorrect’ answer. Total maximum score each diabetic patient can score is 10/10 and a minimum of 0/10. Appropriate statistics were applied to test the results at significance p ≤0.05. Results: Total 581 patients with diabetes were assessed in this study. Patients included were in age range 16 to 85 years with median age of 56 years. Males and females were 60% and 40%, respectively. Among these patients a mean score of 4.5 and median score of 4 was achieved in the questionnaire. 35 (6%) patients achieved the maximum score of 10/10 and 74 (12.7%) patients had a minimum score of 0/10. There was no significant difference in the mean score achieved between males (4.1) and females (3.9). Though it was not statistically significant there was a negative correlation between age and the score (-0.06; p = 0.2). Conclusion: The survey gave us useful insights into the lack of awareness about daily food products in diabetic patients. Majority of them didn’t have adequate knowledge, which recommends for a thorough diet counseling to improve their dietary patterns for better clinical outcomes. Disclosure R.S. Erukulapati: None. S. Yalamanchili: None. S. Rani: None.

Aim: To assess the awareness of dietary constituents, perception of diet in those with diabetes. Methods: A cross-sectional, objective, qualitative questionnaire-based assessment was performed among outpatient diabetes patients who visited tertiary diabetes care centers in Metropolitan cities of India. The questionnaire was answered by diabetes patients in a simple ’Yes’ or ’No’ format about awareness of various foods. The questions were about diet, quantity that could be consumed, and myths about various food products consumed routinely. Patients’ perception of diet was categorized into ’correct’ and ’incorrect’ depending on their response to each question in a 10-point questionnaire. A score of ’1’ was given for each ’correct’ answer and ’0’ for an ’incorrect’ answer. Maximum score one can get is 10/10 and a minimum of 0/10. Results: Total 2295 patients with diabetes were assessed. Patients included were in age range 9 to 90 years with median age of 55 years. Males, females were 62% and 38% respectively. A mean score of 3.8 and median score of 4 was achieved. 2.2% patients achieved maximum correct answer score of 9/10 and 5.9% patients had minimum score 0/10. 44.8% patients scored <4, 45.3% scored 4-6 and 9.9% scored >6. Socioeconomic status, education, HbA1c levels, occupation, Insulin use, duration of diabetes were the factors that contributed to better level of awareness about diet (p <0.001). Age <40 years, male gender, type 1 diabetes, previous diet counseling, exercise patterns, family history of diabetes, unmarried, weight <40kgs, history of no alcohol usage and being non-smoker, were associated with better scores, although not statistically significant. Conclusion: This study gives valuable insights into the lack of awareness about daily food products and the factors associated with the diet perceptions in diabetic patients. This facilitates health care providers to work on areas that could facilitate improving awareness about dietary practices in those with diabetes. Disclosure R.S. Erukulapati: None. M. Rm: None. K. Dash: None. S. Das: None. H. Reddy: None. V. S: None. A. Punjani: None. S. Yalamanchili: None. S. Tippisetty: None. V.K. Kolukula: None. S.G. Krishna: None.

Aim: To evaluate the quality and meaningful interactions of patients with type 2 diabetes mellitus (T2DM) with health coach through Apollo Sugar App and its effects on clinical outcomes. Methods: Apollo Sugar Clinics is a pan-India chain of state of art, integrated care network of diabetes specialty clinics. The current analysis includes digital data of health interactions captured through a novel, unique and well-designed Apollo Sugar App. of great utility value. These live health interactions were between Sugar health coaches and 10,000 patients with T2DM, registered at Apollo Sugar Clinics who downloaded the Apollo Sugar App from Google Play store for the last 6 months. Meaningful health interactions with health coach were identified in 317 patients which were categorized into medication, diet, exercise, and self-monitoring blood glucose (SMBG). Descriptive statistics was applied to analyze the data, to assess clinical outcomes. Results: A total of 10800 health interactions were captured, of which 2000 quality interactions were categorized as meaningful interactions. Among these interactions 29% on diet, 21% on exercise, 19% on medication change, 4% on insulin dose, 2% on hypoglycemia and 25% on meaningful use of SMBG data. SMBG was performed >2times/week by 65% of study population. Pre-meal and post-meal SMBG target were achieved in 35% and 24% of patients, respectively. 28% achieved control reductions in <2 weeks and no hypoglycemic episodes occurred in any of the patients. There was a considerable reduction in mean HbA1c (-0.7%), fasting plasma glucose (-41.5mg/dL) and post-prandial glucose (-100.7mg/dL) at 3 months follow-up. Conclusions: The current analysis indicates that patient interactions with health coach through an Apollo Sugar app is a modern improved method of behavioral and clinical care, to achieve long term continuity of care for change in outcome of hard end points. Disclosure S. Shah: None. R. Mehrotra: None. S. Das: None. R.S. Erukulapati: None. S.P. Reddy: None. J. Jayaprakashsai: None. K. Dash: None. B. Jaganmohan: None. U. Ayyagari: None. S. Tippisetty: None. V.K. Kolukula: None. S. Joshi: None.