In this article, we have discussed the basic knowledge to calculate sensitivity, specificity, positive predictive
value and negative predictive value. We have discussed the advantage and limitations of these measures and
have provided how we should use these measures in our day-to-day clinical practice. We also have illustrated
how to calculate sensitivity and specificity while combining two tests and how to use these results for our
patients in day-to-day practice.
Persons with moderate and severe glaucoma have a dysfunctional ipRGC-mediated PIPR. Intrinsically photosensitive retinal ganglion cell function measured directly with the PIPR may become a clinical indicator of progressive changes in glaucoma.
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