In this article, the oxidation of alcohols into carbonyl compounds was studied in oxygen atmospheres using a copper oxide on graphene oxide (CuO@GO) nano composites catalyst, synthesized by the wet chemistry method. CuO@GO nano composites were prepared from GO, and CuO NPs by the sol-gel method. The transformation of aromatic alcohols into corresponding carbonyl compounds in good-to-high yields were observed using the CuO@GO catalyst under an oxygen atmosphere. Synthesized CuO@GO was confirmed by FT-IR, XRD, XPS, TEM, FE-SEM, TEM, and SEM analyses, and revealed intercalation of CuO-NPs on/in GO nano sheets through the chelation of Cu+2 ions with CO, COOH, and OH groups presenting on the GO nano sheets. The catalytic activity of CuO@GO nano composites for the conversion of alcohols into carbonyl compounds were evaluated through TOF (2.56 × 10−3 mol g−1 min−1). The use of CuO@GO has shown catalytic activity and recyclability with a high conversion of alcohols to ketones. We assume that the proposed CuO@GO catalyst can be used for other key organic transformations and will be evaluated in the future.

Objective: Misoprostol is a synthetic prostaglandin that is related structurally to naturally occurring prostaglandin (PG), and it has been acknowledged as an effective inhibitor of gastric acid secretion when administered intravenously. Methods: In the present study, the novel application of 1,8-Diazabicyclo[5.4.0]undec-7-ene, a cyclic unsaturated amine [DBU] for the conversion of A-type Misoprostol (A-MP) to B-type Misoprostol (B-MP) via intramolecular isomerization. Results: The intramolecular isomerization process was successfully applied for the separation of enantio-pure isomers with no impurities using DBU. Conclusion: The chemical structures of A-MP and B-MP were confirmed using spectral analyses of 1H-NMR, 13C-NMR and Mass spectroscopy.