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Itch is a common problem affecting approximately 13.5% of the population. 1 Itch can result from underlying skin conditions, for example, atopic dermatitis, or from environmental factors such as dry climate or insect bites. A variety of cosmetic and prescription anti-itch products are available. However, the efficacy of most cosmetic products is not sufficient. Prescription or over-the-counter (OTC) drug products are more effective; however, many have significant negative side effects. For example, long-term treatment with corticosteroids has been demonstrated to increase risk of hypothalamus-pituitary axis suppression as well as skin atrophy. 1 As such, there exist an unmet need to develop a safe topical treatment for this common condition.

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