Purpose: To evaluate clinically and radiographically the postoperative success of Propolis, Propolis mixed with Chitosan and Formocresol in pulpotomy procedure for primary molars. Materials and Methods: 30 Primary molars in 10 patients were selected according to the inclusion criteria. In this study pulpotomy was carried out on 30 molars and depending on the type of radicular pulp medicament, the molars were divided randomly and equally into three groups: Group I (formocresol group), Group II (Propolis and Chitosan mixture group) and Group III (Propolis group). Clinical follow up was done after 1, 3 and 6 months. Periapical radiographs also were taken at 1, 3 and 6 months follow up visits. Results: No statistically significant difference between groups in the overall cumulative clinical or radiographic success at follow up visits P value ≤. 0.05 Conclusion: Propolis mixed with Chitosan can be considered as a good natural alternative to formocresol in primary molars pulpotomy.