No abstract

We are writing to highlight the potential for a post-viral syndrome to manifest following COVID-19 infection as previously reported following Severe Acute Respiratory Syndrome (SARS) infection, also a coronavirus. After the acute SARS episode some patients, many of whom were healthcare workers went on to develop a Chronic Fatigue Syndrome / Myalgic Encephalomyelitis (CFS/ME) -like illness which nearly 20 months on prevented them returning to work. We propose that once an acute COVID-19 infection has been overcome, a subgroup of remitted patients are likely to experience long-term adverse effects resembling CFS/ME symptomatology such as persistent fatigue, diffuse myalgia, depressive symptoms, and non-restorative sleep. In a contracted future economy, managing likely Post COVID-19 syndrome cases, in addition to existing CFS/ME cases will put additional burden on our already hard pressed healthcare system. We suggest that priority is given to exploration of pragmatic relatively low cost techniques to treat post-viral fatigue, to alleviate symptoms and improve quality of life for those affected by the longer term sequelae of COVID-19.

Background: The COVID-19 pandemic is causing extensive job loss leading to a loss of social status in many men. Endorsement of traditional masculinity ideology may render some men particularly sensitive to status loss and thereby to an increased risk for suicidality.Methods: In this anonymous online survey conducted in German-speaking European countries, 490 men completed questionnaires regarding loss of social status due to the pandemic, suicidal ideation and past-month suicide attempt. Furthermore, prototypical and male-typical externalizing depression symptoms, self-identified masculine gender orientation, endorsement of traditional masculinity, and gender role conflict were measured.Results: Out of a total of 490 men, 14.7% of men reported experiencing a status loss due to the pandemic. These men were more than twice as likely to report suicidal ideation during the past two weeks, and more than four times as likely to have attempted suicide in the past month than men not reporting a status loss. Depression symptoms, self-identified masculine gender orientation, endorsement of traditional masculinity, but not gender role conflict were positively associated with status loss. Suicidal ideation and suicide attempt were associated with prototypical and male-typical externalizing depression symptoms, but not masculinity- related constructs.Conclusion: Status loss emerges as risk factor for suicide and is associated with depression symptoms, higher masculine gender orientation and endorsement of traditional masculinity. Men with high levels of traditional masculinity and status loss due to the pandemic are at increased risk for suicide.

The effect of ligand interactions with the C3d/C3dg complement receptor (CR2) on proliferation of human B lymphoblastoid cells was investigated by using cell cultures performed at low density (1 to 1.5 x 10(3) cells/ml) in a serum-free defined medium to which only transferrin had been added. This medium does not allow proliferation of Raji cells which die within 48 hr with formation of polykaryons. Addition of purified human C3 to the cultures resulted in a dose-dependent proliferation of the cells. A steady growth of Raji cells with a doubling time of 36 hr was observed in cultures containing 10 micrograms/ml of C3. A growth rate similar to that observed in the presence of native C3 was found in the presence of equimolar concentrations of purified C3dg but not of C3c. F(ab')2 anti-C3d but not F(ab')2 anti-C3c antibodies inhibited the mitogenic effect of C3. Preincubation of Raji cells with monoclonal antibody OKB7 which directly inhibits the binding of C3dg to CR2, totally suppressed C3-induced growth of the cells. C3 did not enhance growth of the T lymphoma-derived cell line JM and monocytic cell line U937 which do not express CR2. These results provide direct evidence that the interaction between CR2 and C3 fragments stimulates proliferation of human cells of the B lineage. Because CR2 also acts as a receptor for Epstein-Barr virus on B cells, our results may pertain to the B cell mitogenic properties of the virus.