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In both families there is evidence of autosomal dominant inheritance of PTC. The association of PTC with MNG suggests a possible role for MNG in tumor pathogenesis in hereditary PTC. The majority of the patients were diagnosed with PTC before commencement of prospective screening, indicating clinically relevant disease in the families described.

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Propranolol was given intravenously to 6 adult patients with essential tremor, using a bolus-infusion regimen for rapid production and maintenance of predicted drug plasma levels. Tremor in the outstretched hand was quantitated by integration of the waveform signal recorded from a miniature accelerometer. Propranolol had no effect on tremor frequency (6 to 8 cps), but it suppressed tremor amplitude in all patients in direct proportion to the drug's plasma concentration and to the intensity of beta-adrenergic blockade produced. Among this group of patients the maximal tremor decrease occurred at plasma levels of about 100 ng per milliliter and varied widely between individuals (18 to 85%), implying that the efficacy ofpropranolol therapy in essential tremor depends on both the plasmadrug level and the innate sensitivity of the disorder in the individual patient.McAllister R G Jr, Markesbery WR, Ware RW, et al: Suppression of essential tremor by propranolol: correlation of effect with drug plasma levels and intensity of beta-adrenergic blockade. Ann Neurol 1: [160][161][162][163][164][165][166] 1977 Beta-adrenergic mechanisms have been implicated in the mediation of tremor in normal subjects [l]