Objectives: Childhood obesity contributes to the risk of numerous health problems and has become a major global health concern. This study aimed to establish the association between obesity and cognitive function among healthy school adolescents. Methods: This study was carried out by taking school adolescents (n = 400) from June 2016 to December 2017. The mean age of the participants was 13.93 ± 0.81 years. The students were divided into group A (obese, n = 223) and B (non-obese, n = 177). Cognitive functions were recorded as per study tool of the Cambridge Neuropsychological Test Automated Battery (CANTAB). Results: Severely obese students showed a significant delay in cognitive functions as compared to students with normal BMI. Attention Switching Task (AST)-Latency among students with normal BMI was 647.88 ± 137.59 compared to the students with high BMI (685.08 ± 115.92, p = 0.05), AST-Incongruent was 680.78 ± 142.07 versus 726.76 ± 122.31 (p = 0.02), AST-Percent correct trials was 84.31 ± 10.45 versus 78.09 ± 14.87 (p = 0.001), and Intra-Extra Dimensional Set Shift (IED) Total errors among students with normal BMI was 33.93 ± 21.53 compared to the students with high BMI (42.86 ± 37.27, p = 0.03). Conclusion: Cognitive functions including AST-Latency, AST-Incongruent, AST-Percent correct trials, and IED Total errors were significantly weakened in markedly obese students. Significant impairments in their cognitive functions, especially attention, retention, intelligence, and cognitive flexibility, were observed. The findings of this study emphasize the need to involve school adolescents in physical activities to reduce body weight in order to have cognitive functions within normal range and also to minimize obesity-associated complications.

Glycine transporter 1 encephalopathy (OMIM# 617301; glycine encephalopathy with normal serum glycine, GLYT1 transporter dysfunction, and nonketotic hyperglycinemia) is caused by mutations in the SLC6A9 gene. To date, 6 cases have been reported in the literature, characterized as having neonatal onset, respiratory failure that required mechanical ventilation, severe hypotonia at birth that progressed to limb hypertonicity, and startle-like responses provoked by sudden loud noises and tactile stimulation. Additional characteristics included dysmorphic features, musculoskeletal abnormalities, and abnormal antenatal findings. Initial diagnosis include elevated levels of glycine in cerebrospinal fluid and an elevated cerebrospinal fluid to plasma glycine ratio. Abnormal magnetic resonance imaging findings included white matter abnormalities, thin corpus callosum, dilatation of the lateral and third ventricles, caudate atrophy, and tiny cysts. Patients reported so far showed normal electroencephalogram results. Treatment was supportive and appeared severe as 50% of the patients died between 2 days and 7 months of age, while surviving children had global developmental delay. In this report, we reviewed the published cases having glycine transporter 1 encephalopathy and retrospectively characterizing the disease phenotypes, affected biochemical pathways, neuroradiological abnormalities, diagnosis, genetic issues, and treatment; additionally, key discussion points are also presented.

Background: Categories of Auditory Performance II (CAP-II) is an established audiological test that consists of a rating scale that can be used for prospective assessment of the auditory performance of cochlear implant (CI) recipients. Objective: To create and validate an Arabic version of Categories of Auditory Performance scale II (CAP-II), and to evaluate its reliability. Methods: In this cross-sectional study, 30 post-CI children (patients’ group) along with 30 control subjects were included. The translated Arabic CAP-II scale has been used by speech-language pathologists and parents to evaluate the study subjects’ auditory abilities. The interrater reliability, test–retest reliability, pre and postintervention score (responsiveness test), case versus control score comparison (discriminate validity), and cross-validation of the new Arabic version of CAP-II have been assessed. Results: The Arabic CAP-II demonstrated high test–retest and inter-rater reliability. There was a positive correlation between the Arabic CAP-II and Meaningful auditory integration scale. The Arabic CAP-II scores were higher in the patients’ group compared with control subjects. Conclusion: The Arabic CAP-II showed high inter-rater reliability with excellent concurrent and discriminate validity. The Arabic version of CAP-II seems to be a valid and reliable tool in assessing different auditory performance in Arabic speaking children with hearing impairment.

The purpose of this study is to determine the average values of the angular nasal anthropometric variables in Arabian women seeking rhinoplasty and compare them with the normal values. A total of 150 female patients, who underwent rhinoplasty between January 2018 and November 2021, were enrolled in this study. The exclusion criteria were a history of nasal trauma, previous rhinoplasty, and a cleft nose. Data were obtained from standardized digital photographic images. Lateral and basal views were analyzed using landmarks defined by a single observer and measurements were performed using Adobe Photoshop Software SC6. All data were analyzed using SPSS version 21 software (IBM) and compared with the normal values obtained from a previous study. All facial angles, except for the nasofrontal angles, were significantly different between the surgical and nonsurgical normal groups. The values (means ± SDs) in the surgical group were as follows: nasofacial angle, 29.7 ± 3.4 degrees; nasofrontal angle, 146.2 ± 2.8 degrees; glabella-nasal angle, 169.8 ± 5.8 degrees; nasolabial angle, 113.5 ± 11 degrees; nasomental angle, 130.6 ± 6 degrees; nasal tip angle, 102.3 ± 8 degrees; ala-slope angle, 95.4 ± 13.6 degrees. The nose characteristics of Arabian women seeking rhinoplasty were as follows: (1) shallow radix, (2) under the projected tip, and (3) normal tip rotation. Surgical planning is important upon consideration of any procedure or modification of the nose among Arabian women.