The study compared effects of maximal resistance training (MRT) versus endurance resistance training (ERT) in overweight people at risk of developing Type 2 Diabetes. Dependent variables included changes in body fat %, upper leg skeletal muscle area (left + right), BMI and body weight pre-to post intervention. Eighteen individuals, 33-69 years of age, were randomly assigned to one of two groups. Group 1 engaged in MRT three days/week over a four month period while members of Group 2 acted as controls. Later, Group 2 engaged in ERT three days/week over a four month period and the members acted as their own controls. Both interventions consisted of eight exercises. Pre-to post changes were significant for MRT with a reduction in BMI (p=0.013) and body weight (p=0.010), while percentage of body fat was significantly reduced (p=0.009) and skeletal muscle area increased (p=0.021) with ERT. The results support both approaches as interventions in primary prevention of obesity and consequently in reducing risk of Type 2 Diabetes.