Bakground and objective: Sleep disorder is among the most common problems in the life of postmenopausal women. Because of the complications of chemical drugs, many women prefer to use herbal supplements for relieving sleep problems. So, the main objective of this study was to determine the effect of the jujube seed capsule on sleep quality in postmenopausal women. Materials and methods: This study was a double-blind clinical trial conducted on 106 postmenopausal women in Khuzestan province, southwest of Iran. All participants were selected by a simple non-probability sampling method. Data were collected through a demographic data form and the Pittsburgh sleeps quality index (PSQI). Individuals were randomly divided into intervention (n ¼ 53) and control (n ¼ 53) groups. The intervention group received 250 mg oral jujube seed capsule and the control group received a placebo capsule twice a day for 21 days. After the treatment, the PSQI was completed in both intervention and control groups. Data were analyzed using the independent t-test and the Chi-square test using SPSS software version 24, and p-value < 0.05 was considered as the significance level. Results: The results revealed that after treatment, the mean scores of sleep quality decreased in the intervention and control group. Although this difference was statistically significant in both intervention and control groups (pvalue < 0.05), more reduction observed in the intervention group (p-value < 0.001). Conclusion: Consumption of the jujube seed capsule had a positive impact on improving the sleep quality of postmenopausal women and could be recommended as a useful herbal medication.

Background and Objectives:Parkinson disease is caused by destruction of dopamine-producing nerve cells. Given the antioxidant properties of Ferulago angulata, the aim of the present study was to investigate the effect of the extract of this plant on motor and memory disorders in animal model of Parkinson's disease. Methods:In this experimental study, 40 male Wistar rats (200-250g), were divided into 5 groups: 1-control; 2-Parkinson, and 3-Parkinson groups receiving chavill extract (doses, 100, 200, and 400mg/kg) by gavage for 14 days. To create animal model of Parkinson disease, the rats received 6-hydroxydopamine neurotoxin into the left medial forebrain bundle (MFB) of the brain. One day after the last gavage, motor and memory tests were performed in the rats. One-way ANOVA and Tukey's post hoc test were used to determine the difference between the groups.Results: Fourteen days after lesion formation in the MFB, following apomorphine injection in the right direction, the rats had a rate of more than 10 rounds per minute with rotation of 360 degrees. In the motor test of the Parkinson's group, maintaining balance on the rotarod (p<0.01), time of keeping hands on horizontal bars (p<0.001), muscle stiffness (p<0.001), step length (p<0.001), and avoidance memory (p<0.001) showed a significant difference compared to the control group. Ferulago extract significantly improved various types of motor disorders caused by Parkinson disease and 200 and 400 doses improved memory in the Parkinson rats (p<0.05). Conclusion:Intraperitoneal administration of Ferulago extract has a protective effect against 6-hydroxydopamine in the experimental model of Parkinson Disease.