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Introduction In this review, we discuss the evidence for a novel receptor, vitamin D metabolite, 1,25-dihydroxyvitamin D 3. The protein, which we have termed as the membrane-associated, rapid response steroid-binding (1,25D 3-MARRS) receptor, is identical to ERp57/PDIA3. This protein has been extensively studied for its role in calcium and phosphate uptake in intestinal cells and more recently has been found to be implicated in cancer and Alzheimer's disease. In addition, we present a more complete biochemical characterisation of this protein using co-immunoprecipitation and chromatin immunoprecipitation studies. Conclusion The 1,25D 3-MARRS protein has both cytoplasmic and nuclear motifs and redistribution within the cell. New evidence shows its potential involvement through genomic action. Its involvement in disease states appears primarily through its chaperone action, post-translational modification of vital proteins and ability to modulate oxidative stress.

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