In 2017, a comprehensive review of groundwater resources in Jordan was carried out for the first time since 1995. The change in groundwater levels between 1995 and 2017 was found to be dramatic: large declines have been recorded all over the country, reaching more than 100 m in some areas. The most affected areas are those with large-scale groundwater-irrigated agriculture, but areas that are only used for public water supply are also affected. The decrease of groundwater levels and saturated thickness poses a growing threat for drinking water supply and the demand has to be met from increasingly deeper and more remote sources, causing higher costs for drilling and extraction. Groundwater-level contour lines show that groundwater flow direction has completely reversed in some parts of the main aquifer. Consequently, previously established conceptual models, such as the concept of 12 “groundwater basins” often used in Jordan should be revised or replaced. Additionally, hydraulic conditions are changing from confined to unconfined; this is most likely a major driver for geogenic pollution with heavy metals through leakage from the overlying bituminous aquitard. Three exemplary case studies are presented to illustrate and discuss the main causes for the decline of the water tables (agriculture and population growth) and to show how the results of this assessment can be used on a regional scale.