Corneal confocal microscopy and familial amyloidotic polyneuropathy ଝ Microscopie confocale cornéenne et polyneuropathie amyloïde familiale Purpose To describe a case of familial amyloidotic polyneuropathy (FAP) with corneal amyloid deposits found using corneal confocal microscopy (CCM). Case description A complete ophthalmological examination with glaucoma assessment and CCM (Heidelbergh Retina Tomograph II with Rostock cornea module) were performed in a patient with FAP. Color photographs of the anterior segment were also taken. ଝ Written communication presented at the 124th Congress of the French Ophthalmology Society in May 2018.

Purpose Aquaporin‐1 (AQP1) is involved in cell migration and proliferation. This study aims to investigate AQP1 expression in membranes from proliferative vitreoretinopathy (PVR) and epiretinal membranes (ERM) Methods 20 Membranes PVR and ERM were collected following eye surgery from 20 eyes from 20 patients. AQP1 mRNA and protein expression were determined by RT‐qPCR and immunofluorescence in both PVR and ERM Results AQP1 mRNA and protein were expressed in both PVR and ERM as shown by both RT‐qPCR and immunofluorescence. Moreover, AQP1 protein expression was heterogeneous among and between PVR and ERM, and was highly colocalized with alpha‐smooth muscle actin (SMA or Acta2) and slightly colocalized with glial fibrillary acidic protein (GFAP). Conclusion AQP1 mRNA and protein were expressed in membranes from PVR and in ERM. Due to the absence of SMA and GFAP colocalization, it is likely that AQP1 is expressed by at least two distinct cells types. AQP1 might play a role in cell migration and proliferation occurring during the formation of PVR and ERM, and could represent a new therapeutic target

Purpose. Aquaporin-1 (AQP1) is involved in cell migration and proliferation; therefore, the purpose of the study was to investigate its expression in proliferative vitreoretinopathy (PVR) and epiretinal membranes (ERM). Methods. 19 membranes from PVR and ERM were collected following eye surgery. AQP1 mRNA and protein expressions were determined by RT-qPCR and immunofluorescence in the membranes from PVR and ERM. Results. AQP1 mRNA and protein were expressed in both PVR and ERM as shown by RT-qPCR and immunofluorescence. AQP1 protein expression was heterogeneous among and between PVR and ERM and colocalized with alpha-smooth muscle actin (αSMA) and with glial fibrillary acidic protein (GFAP). There were a higher percentage of cells coexpressing AQP1 and αSMA than AQP1 and GFAP. GFAP and αSMA did not colocalize. Conclusion. Our data show for the first time AQP1 expression in both PVR and ERM. AQP1 is expressed mostly by the αSMA-positive cells, presumably myofibroblasts, but also by GFAP-positive cells, assumed to be glial cells. These original findings warrant further functional investigations aiming at studying the potential role of AQP1 in cell migration and proliferation occurring during the development of PVR and ERM.