No abstract

Onco-hypertension is an emerging field investigating the relationship between hypertension and cancer. This paper details one part of this relationship—the effect of anti-cancer agents on blood pressure. We review the evidence linking targeted therapies, immunotherapy, traditional chemotherapies, and hormonal agents with hypertension. Proposed pathophysiological mechanisms vary by drug but include endothelial dysfunction, altered sodium homeostasis, and nephrotoxicity. Despite growing interest in the field, there is a paucity of data on the clinical significance of treatment related hypertension and the optimal management strategy. This should be a focus of future studies.

The aim of the research. To evaluate the frequency of prescribing different groups of antihypertensive drugs (AGP) in the treatment of patients with hypertension in patients of Krasnoyarsk Region according to all-Russian epidemiological study ESSE-RF. Materials and methods. There were examined 1603 people aged 25-64, selected by systematic multistage stratified randomization among the population attached to the four polyclinics of Krasnoyarsk and Berezovskiy District Hospital. All included were subjected to detailed questioning, and office BP measurement. The frequency of assigning different groups of AGP was assessed taking into account gender, age, level of education and type of settlements. Results. The share of persons on monotherapy was 53.4%. The most frequently taken antihistamines, including combination therapy, were ACE inhibitors-in 51% of cases, beta-blockers-28.9%, angiotensin receptor blockers (ARBs)-25.2%, diuretics-23.2%, calcium channel blockers (CCBs)-11.9%, centrally acting drugs-2.0% and alphablockers-0.4%. Beta-blockers are used more often by the young persons-38.1%, mainly men aged 25-34 (50.0%). Among the combinations of AGP are most often found combination of ACEI + diuretic (6.8%), then by the prescribing frequency-ARB + diuretic, a beta-blocker + diuretic, ARB + CCB, ACEI + CCB. Conclusion. It was noted frequent prescribing of ACE inhibitors and little use of drugs of the central action. It is troubling a high level of use the monotherapy by antihypertensive drugs in patients with hypertension (53.4%), that may be one of the reasons for the relatively low rate of effectiveness at antihypertensive therapy (31.6%). Unreasonably often are prescribed beta-blockers to young men aged 25-34 years with hypertension.

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