Objectives: The aim was to find out the prevalence of psychoactive substance use among female students in Ain Shams University, Cairo, and to investigate associations between substance use and some selected sociodemographic factors. Materials and Methods: A total of 600 female students in their final year of college was recruited from six faculties of Ain Shams University; 3 practical faculties (medicine, dentistry, pharmacy) and 3 theoretical faculties (commerce, arts, law), 100 students from each. They completed the Structured Questionnaire for the Detection of Drug Intake and the Assessment of Sociodemographic Data which is a self-administered questionnaire used for the detection of substance use among university students. Results: The most commonly used substance was illicit drugs (9.8%), followed by tobacco (9%). Tobacco smoking was more prevalent between faculty of arts students and tobacco and cannabis use were more prevalent among theoretical faculties students. Being from Cairo, high family income, high daily pocket money, interneting as the main leisure time activity, and having friends or close relatives with substance use were positively associated with substance use among female university students. Conclusion: Illicit drugs were the most common substance used among female university students in Egypt. Substance use was influenced by sociodemographic factors; faculty, form of study, residence and living arrangement, parental education, income, leisure time activities, and having friends or relatives with substance use.

Background Study of cortisol levels in patients with ADHD in correlation with aggressive behaviors associated with ADHD has received limited research attention. This factor is essential for comprehending the psychopathophysiology of ADHD and its comorbidities. The present study aimed to investigate the cortisol level in ADHD children and its relation to severity of symptoms and associated aggressive behavior in those children. The sample consisted of 129 patients and 80 healthy controls evaluated by administering the Mini International Neuropsychiatric Interview for Children, The Wechsler Intelligence Scale for Children, Conners’ parent rating scale, problem scale of C.B.C.L., and Socioeconomic Status Scale. Salivary cortisol was measured using radio-immune assay. Results Salivary cortisol level in our ADHD subjects was significantly lower (11.826 ng/ml) than in the control group (19.619 ng/ml with P-value 0.001). Our results failed to find any correlation between ADHD symptoms severity and salivary cortisol levels. Severity of delinquent, aggressive, and externalizing behaviors of ADHD children positively correlated with cortisol salivary levels. Conclusion Salivary cortisol levels are lower in children with ADHD relative to age- and sex-matched healthy controls. In addition, there is no obvious correlation between severity of ADHD symptoms and basal salivary cortisol levels. We also concluded that there is positive correlation between delinquent, aggressive, and externalizing behaviors in children with ADHD and their basal salivary cortisol levels.

Background Several studies pointed to immune dysregulation abnormalities linked to autism spectrum disorders (ASD). Of those, several autoantibodies had been identified. Recent findings of N-methyl d-aspartate (NMDA) antibodies in autoimmune encephalitis suggested that it caused symptoms like autistic regression. Thus, the purpose of the study was to test for the presence of anti-NMDAR antibodies in the ASD disorder population and to correlate this with the clinical findings. Results Eighty-seven autistic children, 4–12 years old, were enrolled in the study and were matched with sixty typically developing children used as controls. The diagnosis of cases was confirmed by ADOS-2 and clinical evaluation. None of the control children had positive anti-NMDAR antibodies, while 26.4% (23 children) of the patients’ group were positive for serum anti-NMDA receptor antibodies (> 200 pg/ml, p = 0.0157). The positive anti-NMDAR antibody was statistically correlated with better speech stage (p = 0.017), more severe stereotyped behavior (p ≤ 0.001), and abnormal EEG findings (p = 0.025). Conclusions There is a possibility of the presence of anti-NMDAR antibodies in the autism spectrum disorder population with certain characteristics, especially the severity of the stereotyped behaviors.

BACKGROUND:Clozapine has demonstrated its clinical efficacy in resistant schizophrenia not only to treat positive, negative and cognitive symptoms but also to improve psychosocial functioning.The objective of our study was to describe the sociodemographic, clinical and outcome characteristics of patients with treatment resistant schizophrenia (TRS) and to identify predictors of global functioning of patient undertaking clozapine.