ABSTRACT:Introduction: Diabetic foot is one of the common complications associated with diabetes. The treatment of metformin may help in reducing the prevalence of diabetic foot ulcer among diabetic patients.

ABSTRACT:Introduction: Diabetes is associated with abnormalities in lipid profile. The treatment with aspirin may have regulatory effects in lipid profile and accordingly may help in protecting against metabolic abnormalities associated with diabetes. Study objective:To explore the impact of aspirin treatment on dyslipidemia in diabetic patients who attend outclinics of Jordanian Royal Medical Services.Methods and subjects: This study was based on the retrospective design to collect data from files of diabetic patients. Data was collected from appropriate files in which the required information is provided. Study variables include demographic variables such as gender and age; clinical variables related to diabetes such as duration, aspirin treatment, and lipid profile. Data were gathered and analyzed using SPSS version 21. Statistical analyses such as descriptive statistics were used. The relationship between study variables was analyzed as required such as Chisquare, andOne way Anova. Significance was examined at alpha <0.05. Results:The study included 62 diabetic patients. The mean age of participants was 56.95± 11.98 years. About 53% of participants were males. Duration of diabetes was 7.51±5.86 years. Fifty percent of participants used aspirin; the mean aspirin dose was 111.36±24.67 mg. about 60% of patients had dyslipidemia. The mean level of cholesterol was 217.70±51.58 mg/dl, while the mean level of TG was 246.94±172.40 mg/dl, and that of HDL was 45.89±13.027 mg/dl, and that of LDL was 118.32±41.33 mg/dl. Dyslipidemia was not significantly associated with gender or aspirin use. Using One Anova test, dyslipidemia was significantly associated with diabetes duration (p=0.05), cholesterol level (p=0.029), and aspirin dose (p=0.016). Conclusions:The present study showed a significant relationship between dyslipidemia and aspirin use, diabetes duration, and aspirin dose.

ABSTRACT:Introduction: Diabetes is associated with the involvement of defects in the nervous system which leads to diabetic neuropathy. Treatment with aspirin has been associated with improvement of several diseases.