Background: The progress in the field of dental adhesion has shown great implications for restorative dentistry. Immediate dentin sealing is a technique that was introduced to improve the bonding of indirect restorations. The improvement of bonding techniques to both enamel and dentin promotes the practice of conservative dental treatment.Hencethe purpose of the current study was to search for the best available evidence concerning the clinical outcomes of immediate dentin sealing. Methodology: An extensive search was performed using different online databases (Pubmed, Scopus, Web of Science, Google Scholar and Cochrane library). These search engines were searched for relevant articles by developing relevant search strategies. Three independent authors reviewed studies, collected data, and assessed risk of bias. Results: After reviewing 221 studies, duplicates were removed and inclusion and exclusion criteria were applied. Finally, three clinical studies were accepted in this review. Conclusions: Previous in vitro studies have shown improved outcomes, although there was no strong evidence in clinical studies to prove superiority of this clinical approach.