and the results are expressed as means± SD for continuous variables and as percentages (%) for categorical variables. Results 71 patients (53.3% women, mean age 82.7±6.7 (58-94) years) were treated with an AChEI. 74.6% (53 patients) were simultaneously treated with a DAP. Mean concomitant prescribed drugs (DAP and non-DAP) was 11.6±4.7 drugs (2-26). Prescribed AChEI were rivastigmine 56.3%, donepezil 38% and galantamine 5.6%. According to the classification of the systematic review of Durán et al, 71 patients were treated with a total of 95 DAP. The seven most frequently prescribed anticholinergic drugs were: quetiapine 39.4%, haloperidol 22.5%, ipratropium 21.1%, trazodone 14.1%, risperidone 12.7%, mirtazapine 7% and tramadol 5.6%. 57.7% of patients had dementia symptoms: confusional syndrome 31%, cognitive impairment 28.2%, mood disturbances 12.9% and somnolence 9.9%. The main destination was hospitalisation 85.9%, followed by hospital discharge 11.3% and death 2.8%. Conclusion and relevance A high percentage of elderly patients with dementia treated with AChEI were taking concomitant DAP, that present accumulated risk. The combined use of these drugs can increase cognitive impairment and also antagonise the effects of AChEI. The results of the study suggest the need for considering other treatment options or a decrease in the prescriptions for DAPs to reduce the pharmacological interactions and the related adverse effects of concomitant use.

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Introduction Previous studies that investigated the clinical characteristics of sexual dysfunction in men in Saudi Arabia are limited. This study aimed to explore the clinical characteristics of sexual dysfunction in men visiting an andrology clinic in Saudi Arabia. Objective This study aimed to explore the clinical characteristics of sexual dysfunction in men visiting an andrology clinic in Saudi Arabia. Methods This study is a retrospective single-center cross-sectional study. A random sampling method was used to recruit participants between March and September 2019. Descriptive statistics were used to describe patients’ characteristics. Continuous data were reported as mean ± SD. Chi-squared and multiple logistic regression were used to find the associations between patient's age (older and younger than 50 years) and clinical characteristics of the participants. Results In total, 21.3% participants had diabetes and 9.5% had hypertension. More younger males suffered from sexual problems (69.8%) compared to older males (30.2%). Also, 37.5% participants were overweight, while 25.3% had class I obesity. Most participants had normal follicle stimulating hormone, prolactin, testosterone, luteinizing hormone, and prostate specific antigen levels. Approximately 69.5% had vitamin D insufficiency. Among those older than 50 years, 80.2% had diabetes (P < 0.05). Younger smokers accounted for 79% of the population, with a significant association between patient's age and smoking status (P < 0.05). Patients younger than 50 years with normal A1C levels had a 2.5 times higher risk of having sexual problems (P < 0.00, confidence interval 1.63–3.91). Conclusions MSD may be considered to be caused by other nonorganic problems. There is a significant need to increase Saudi men's awareness of sexual medicine. Disclosure No