Three different, new germanium initiators were used for ring‐opening polymerization of L‐lactide. Chlorobenzene and 120 °C was a usable polymerization system for solution polymerization, and the results from the polymerizations depended on the initiator structure and bulkiness around the insertion site. The average molecular weights as measured by size exclusion chromatography increased linearly with the monomer conversion, and the molecular weight dispersity was around 1.2 for initiators 1 and 2, whereas it was around 1.4 for initiator 3. The average molecular weight of poly(L‐lactide) could be controlled with all three initiators by adding different ratios of monomer and initiator. The reaction rate for the solution polymerization was, however, overall extremely slow. With an initial monomer concentration of 1 M and a monomer‐to‐initiator ratio of 50, the conversion was 93% after 161 h for the fastest initiator. In bulk polymerization, 160 °C, the conversion was 90% after 10 h. © 2003 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 41: 3074–3082, 2003

Cross-reactivity among the two diverse viruses is believed to originate from the concept of antibodies recognizing similar epitopes on the two viral surfaces. Cross-reactive antibody responses have been seen in previous variants of SARS and SARS-CoV-2, but little is known about the cross reactivity with other similar RNA viruses like HIV-1. In the present study, we examined the reactivity the SARS-CoV-2 directed antibodies, via spike, immunized mice sera and demonstrated whether they conferred any cross-reactive neutralization against HIV-1. Our findings show that SARS-CoV-2 spike immunized mice antibodies cross-react with the HIV-1 Env protein. Cross-neutralization among the two viruses is uncommon, suggesting the presence of a non-neutralizing antibody response to conserved epitopes amongst the two viruses. Our results indicate, that SARS-CoV-2 spike antibody cross reactivity is targeted towards the gp41 region of the HIV-1 Env (gp160) protein. Overall, our investigation not only answers a crucial question about the understanding of cross-reactive epitopes of antibodies generated in different viral infections, but also provides critical evidence for developing vaccine immunogens and novel treatment strategies with enhanced efficacy capable of recognising diverse pathogens with similar antigenic features.

Data Mining is an important aspect for any business. Most of the management level decisions are based on the process of Data Mining. One of such aspect is the association between different sale products i.e. what is the actual support of a product respected to the other product. This concept is called Association Mining. According to this concept we define the process of estimating the sale of one product respective to the other product. We are proposing an association rule based on the concept of Hardware support. In this concept we first maintain the database and compare it with systolic array after this a pruning process is being performed to filter the database and to remove the rarely used items. Finally the data is indexed according to hashing technique and the decision is performed in terms of support count.

Cold atmospheric plasma (CAP) is a promising technology quite useful in many industries including biotechnology, biomedical, textiles, and food processing. The contrivance of plasma technology can be a potential game-changer to use in any possible way in these industries. This CAP technology is technically a green process with no generation of chemically harmful substances with more ecological and economic benefits. This review article will focus on the research done in the textile industry and food processing, how plasma brings in an effective change in these industrial sectors as well the as application of CAP in disinfection, sterilization, microbial inactivation, and surface modification to obtain desirable results. Recently, there have been reports of successful use of CAP technology for surface inactivation of SARS-CoV-2, plasma-activated water for disinfection of SARS-CoV-2. This article will streamline the innovations in textiles and food industries achieved using plasma technology and what gaps industries face while manufacturing. The focus will be on what research has already done while depicting the gaps and opportunities for using plasma technology in these industries and making use of it to achieve a circular economy, which is one of the major policies of the European countries. A circular economy enables manufactures to produce goods which can be reused, recycled, refurbished, and repaired rather than scrapping them after a single use. The reduction of harmful chemicals, wastewater treatment, and sterilization is achieved using plasma technology and allows reusing the resources which consequently helps to achieve most of the UN’s sustainable development goals and help society to live a sustainable and better life.

We used human semi-synthetic phage antibody gene libraries to select anti-SARS-CoV-2 RBD scFv antibody fragment and subsequent characterization of this novel tetravalent monoclonal antibody targeting conformational epitopes in the receptor binding domain of SARS-CoV-2. Binding studies suggest that II62 tetravalent antibody cross-reacts with RBD protein of SARS-CoV2 and its different variants of concerns. The epitope mapping data reveals that II62 tetravalent antibody targets an epitope that does not directly interferes with RBD: ACE2 interaction. Neutralization studies with live authentic SARS-CoV2 virus suggests that increase in valency of II62 mAb from monovalent to tetravalent doesn’t perturbate virus interactions with the ACE2 expressing host cells in cytopathic effect-based (CPE) assay. Supplementary Information The online version contains supplementary material available at 10.1007/s13205-022-03272-6.