Consecutive substitution reactions of arsenic(III)chloride with sodium salts of various oximes and morpholinedithiocarbamate (morphdtc) were carried out in 1:2:1 stoichiometry to obtain six new arsenic(III) mixed derivatives of the type: [(R)(R1)C = NO]2Sb[S2CN(CH2CH2)2O] [where R is –C6H5, R1 = –CH3 (1); R = –C6H4CH3, R1 = –CH3 (2); R = –C6H4Cl, R1 = –CH3 (3); R = –C6H4Br, R1 = –CH3 (4); R = –C6H4OH, R1 = –H (5); R(R1)C =  (6)]. These derivatives are characterized by elemental and physicochemical analyses and the tentative distorted trigonalbipyramidal geometry around arsenic assigned using spectral data of infrared (1H, 13C) nuclear magnetic resonance and liquid chromatography‐mass. Powder X‐ray diffraction study revealed their nanoranged particle size to be approximately 40 nm and crystalline nature. These derivatives examined against microbes and results revealed that these derivatives expressed more antifungal potential than antibacterial. The antioxidant activity was carried out by ferric reducing ability of plasma assay, and the cytotoxic study was performed in 3T3 fibroblast cell lines by tetrazolium‐based colorimetric assay.

C=CÀ CH 2 À (CH 2 ) 3 À CH 2 (1 F)] by consecutive substitution of Ph 3 AsBr 2 with sodium salt of substituted oximes and morpholinedithiocarbamate in equimolar proportion. Distorted octahedral geometry was proposed around the arsenic atom, for these derivatives. Nano ranged particle size ∼ 35 nm with crystalline nature was obtained by powder XRD study for these deriva-tives. The derivatives were examined for bacteria and fungi which exhibited higher antifungal capability than antibacterial. Cytotoxic and antioxidant activities were performed through MTT test in 3T 3 fibroblast cell lines and by FRAP assay, respectively for these derivatives. Amongst six triphenylarsenic(V) mixed ligand derivatives, 1 A, 1 B and 1 C were observed non-noxious (cell viability > 50 % even at 500 μg/mL) in nature and 1 D, 1 E and 1 F were poisonous to 3T 3 fibroblast cell lines. Structural-Activity relationship for antimicrobial and antioxidant activity amongst six derivatives 1 A-1 F was explored.