Indistinguishable single photons are key ingredient for a plethora of quantum information processing applications ranging from quantum communications to photonic quantum computing. A mainstream platform to produce indistinguishable single photons over a wide spectral range is based on biphoton generation through spontaneous parametric down-conversion (SPDC) in nonlinear crystals. The purity of the SPDC biphotons, however, is limited by their spectral correlations. Here, we present a design recipe, based on a machine-learning framework, for the engineering of biphoton joint spectrum amplitudes over a wide spectral range. By customizing the poling profile of the KTiOPO4 (KTP) crystal, we show, numerically, that spectral purities of 99.22%, 99.99%, and 99.82% can be achieved, respectively, in the 1310-nm, 1550-nm, and 1600-nm bands after applying a moderate 8-nm filter. The machine-learning framework thus enables the generation of near-indistinguishable single photons over the entire telecommunication band without resorting to KTP crystal's group-velocity-matching wavelength window near 1582 nm.