SARS-CoV-2, a novel coronavirus mostly known as COVID-19 has created a global pandemic. The world is now immobilized by this infectious RNA virus. As of June 15, already more than 7.9 million people have been infected and 432k people died. This RNA virus has the ability to do the mutation in the human body. Accurate determination of mutation rates is essential to comprehend the evolution of this virus and to determine the risk of emergent infectious disease. This study explores the mutation rate of the whole genomic sequence gathered from the patient's dataset of different countries. The collected dataset is processed to determine the nucleotide mutation and codon mutation separately. Furthermore, based on the size of the dataset, the determined mutation rate is categorized for four different regions: China, Australia, the United States, and the rest of the World. It has been found that a huge amount of Thymine (T) and Adenine (A) are mutated to other nucleotides for all regions, but codons are not frequently mutating like nucleotides. A recurrent neural network-based Long Short Term Memory (LSTM) model has been applied to predict the future mutation rate of this virus. The LSTM model gives Root Mean Square Error (RMSE) of 0.06 in testing and 0.04 in training, which is an optimized value. Using this train and testing process, the nucleotide mutation rate of 400 th patient in future time has been predicted. About 0.1% increment in mutation rate is found for mutating of nucleotides from T to C and G, C to G and G to T. While a decrement of 0.1% is seen for mutating of T to A, and A to C. It is found that this model can be used to predict day basis mutation rates if more patient data is available in updated time.

The disease may be an explicit status that negatively affects human health. Cardiopathy is one of the common deadly diseases that is attributed to unhealthy human habits compared to alternative diseases. With the help of machine learning (ML) algorithms, heart disease can be noticed in a short time as well as at a low cost. This study adopted four machine learning models, such as random forest (RF), decision tree (DT), AdaBoost (AB), and K-nearest neighbor (KNN), to detect heart disease. A generalized algorithm was constructed to analyze the strength of the relevant factors that contribute to heart disease prediction. The models were evaluated using the datasets Cleveland, Hungary, Switzerland, and Long Beach (CHSLB), and all were collected from Kaggle. Based on the CHSLB dataset, RF, DT, AB, and KNN models predicted an accuracy of 99.03%, 96.10%, 100%, and 100%, respectively. In the case of a single (Cleveland) dataset, only two models, namely RF and KNN, show good accuracy of 93.437% and 97.83%, respectively. Finally, the study used Streamlit, an internet-based cloud hosting platform, to develop a computer-aided smart system for disease prediction. It is expected that the proposed tool together with the ML algorithm will play a key role in diagnosing heart diseases in a very convenient manner. Above all, the study has made a substantial contribution to the computation of strength scores with significant predictors in the prognosis of heart disease.

Compelling facial expression recognition (FER) processes have been utilized in very successful fields like computer vision, robotics, artificial intelligence, and dynamic texture recognition. However, the FER’s critical problem with traditional local binary pattern (LBP) is the loss of neighboring pixels related to different scales that can affect the texture of facial images. To overcome such limitations, this study describes a new extended LBP method to extract feature vectors from images, detecting each image from facial expressions. The proposed method is based on the bitwise AND operation of two rotational kernels applied on LBP(8,1) and LBP(8,2) and utilizes two accessible datasets. Firstly, the facial parts are detected and the essential components of a face are observed, such as eyes, nose, and lips. The portion of the face is then cropped to reduce the dimensions and an unsharp masking kernel is applied to sharpen the image. The filtered images then go through the feature extraction method and wait for the classification process. Four machine learning classifiers were used to verify the proposed method. This study shows that the proposed multi-scale featured local binary pattern (MSFLBP), together with Support Vector Machine (SVM), outperformed the recent LBP-based state-of-the-art approaches resulting in an accuracy of 99.12% for the Extended Cohn–Kanade (CK+) dataset and 89.08% for the Karolinska Directed Emotional Faces (KDEF) dataset.

Analysing the human voice has always been a challenge to the engineering society for various purposes such as product review, emotional state detection, developing AI, and much more. Two basic grounds of voice or speech analysis are to detect human gender and the geographical region based on accent. This study presents a three-layer feature extraction method from the raw human voice to detect the gender as male or female, as well as the region from where that voice belongs. Fundamental frequency, spectral entropy, spectral flatness, and mode frequency have been calculated in the first layer of feature extraction. On the other hand, Mel Frequency Cepstral Coefficient has been used to extract the features in the second layer and linear predictive coding in the third layer. Regular voice contains some noises which have been removed with multiple audio data filtering processes to get noise-free smooth data. Multi-Outputbased 1D Convolutional Neural Network has been used to recognize gender and region from a combined dataset which consists of TIMIT, RAVDESS, and BGC datasets. The model has successfully predicted the gender with 93.01% and region with 97.07% accuracy. This method works better than usual state-ofthe-art methods in separate datasets along with the combined dataset on both gender and region classification.

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