This paper applies an exergy-based method on the two-dimensional airfoil and various threedimensional wing planforms to investigate the impact of exergy on aerodynamic designs. Our intent here is to report our efforts to couple a numerical code with an exergy analysis, a shape shifting algorithm and an optimization code to achieve desired airfoil and wing shapes. Exergy-based optimization is performed to minimize entropy generated on simple airfoils under turbulent flow conditions. Entropy generation and its relationship to total and induced drag are studied for different twisted wing shapes.