Never before have expectations of healthcare professionals been more challenged by complex diseases and more educated patients in increasingly consumer driven healthcare systems. A new era of Precision Medicine (PM) is gaining momentum to bring tailored interventions to patients, informed by genomics, lifestyle and environment. The delivery of a more precision approach requires targeted training to frontline health care professionals. The objective of this paper is to report on the structured design and planning of online training modules for Primary Care Professionals (PCPs) specifically targeted at family doctors, pharmacists and advanced practice nurses. We report on initial findings of an ongoing mixed-method approach initiating applied research in a process where each method informs, guides and refines the design of the next step. Kern's 6 Steps method serves as development framework. Literature and experts' reviews supported clarification of learning objectives, focus groups, guided by Kirkpatrick's levels of evaluation supports refinements of content and form. The findings to date support the need to use methods that will challenge pre-existing assumptions, employ best practice approaches informed by evidence and ensure the development of a quality online training programme acceptable and applicable to the defined target groups.