In this short-term study, MLN02 was more effective than placebo for the induction of clinical and endoscopic remission in patients with active ulcerative colitis.

No abstract

The proportion of oligosaccharide chains on the Fc fragment of IgG which terminate with N-acetylglucosamine (GIcNAc) rather than galactose is increased in rheumatoid arthritis and tuberculosis, and in sera from patients with Crohn's disease, probably because of decreased activity of a galactosyltransferase in B lymphocytes. We We confirm here that the percentage of agalactosyl IgG rises in Crohn's disease, show that it also rises in a minority of patients with ulcerative colitis, and investigate its relationship to clinical and biochemical parameters in both diseases.

No abstract