Cancer cells often fail to respond to stimuli that normally activate their intrinsic apoptotic machinery. Moreover, they are able to adapt to hypoxia by changing their glycolytic rate. Pyruvate kinase (PK) is a rate-limiting enzyme in glycolysis that is converted to a less active dimer form of PKM2 isoenzyme during oncogenesis. Here, we show that both somatostatin and the structural analogue TT-232 interact with the PKM subtype. We further show that the PKM2 is translocated to the nucleus in response to TT-232 and different apoptotic agents. Nuclear translocation of PKM2 is sufficient to induce cell death that is caspase independent, isoform specific, and independent of its enzymatic activity. These results show that the tumor marker PKM2 plays a general role in caspaseindependent cell death of tumor cells and thereby defines this glycolytic enzyme as a novel target for cancer therapy development. [Cancer Res 2007;67(4):1602-8]

Background Physical inactivity is a global phenomenon in European welfare countries. Proper monitoring is essential to measure the physical activity level of the population. Methods In the Hungarian cohort of the European Physical Activity and Sport Monitoring System (EUPASMOS) project, our participants (N = 598) completed sociodemographic questions and the International Physical Activity Questionnaire – short form (IPAQ-SF) survey. The validity and reliability of the subjective measurement tool were examined, IPAQ-SF outcomes were contrasted against triaxial RM42 accelerometer wore for 7 consecutive days. Results The IPAQ-SF showed moderate internal consistency (Cronbach Alpha = 0.647). The concurrent validity of the IPAQ-SF to triaxial accelerometer indicated a significant weak-to-moderate correlation (R = 0.111–0.338, p = 0.042; p < 0.001). The test-retest reliability showed a significant correlation between two measurements (R = 0.788–0.981, p < 0.001). Conclusion The Hungarian version of the IPAQ-SF had excellent test-retest reliability, but low-to-fair concurrent validity for moderate and vigorous physical activity, walking and sitting time, as compared to the objective criterion measure among Hungarian adults.

Background: Physical activity (PA) surveillance, policy, and research efforts need to be periodically appraised to gain insight into national and global capacities for PA promotion. The aim of this paper was to assess the status and trends in PA surveillance, policy, and research in 164 countries. Methods: We used data from the Global Observatory for Physical Activity (GoPA!) 2015 and 2020 surveys. Comprehensive searches were performed for each country to determine the level of development of their PA surveillance, policy, and research, and the findings were verified by the GoPA! Country Contacts. Trends were analyzed based on the data available for both survey years. Results: The global 5-year progress in all 3 indicators was modest, with most countries either improving or staying at the same level. PA surveillance, policy, and research improved or remained at a high level in 48.1%, 40.6%, and 42.1% of the countries, respectively. PA surveillance, policy, and research scores decreased or remained at a low level in 8.3%, 15.8%, and 28.6% of the countries, respectively. The highest capacity for PA promotion was found in Europe, the lowest in Africa and low- and lower-middle-income countries. Although a large percentage of the world’s population benefit from at least some PA policy, surveillance, and research efforts in their countries, 49.6 million people are without PA surveillance, 629.4 million people are without PA policy, and 108.7 million live in countries without any PA research output. A total of 6.3 billion people or 88.2% of the world’s population live in countries where PA promotion capacity should be significantly improved. Conclusion: Despite PA is essential for health, there are large inequalities between countries and world regions in their capacity to promote PA. Coordinated efforts are needed to reduce the inequalities and improve the global capacity for PA promotion.

Background Walkability is a new definition in sport and health science in Hungary. In our study the walkability was measured by NEWS-Hungarian questionnaire first time in Hungary and our research aim was to compare neighbourhood walkability to physical activity level. Methods The study comprised 593 participating adults (248 males and 345 females). The data was collected during February-May 2019 using quota sampling by age and gender representing the Hungarian adult (18+) population. The physical activity was measured by RM 42 hip-worn triaxial accelerometer for 7 consecutive days using vigorous, moderate to vigorous activities and daily steps scores. The walkability was measured by walking and cycling facilities subscale (10 questions) of NEWS-Hungarian questionnaire. The subscale measured the environment's possibilities and quality for walking and cycling. Data were presented as mean ± standard deviation, Spearman's rank correlation was used to analyse data using SPSS 24. program, where level of significance was set at p &gt; 0.05. Results The mean age of the participants was 44.41±18.64 and their average number of daily steps was 7308.47±6993.86. 69.05% was lived in cities and 30.05% in rural areas. The respondent's opinion about the walking and cycling around their place of living was measured by a 4 point scale (1 = strongly disagree and 4 = strongly agree), where we found 2.76±2.8 mean scores. The walkability score was showed significant but weak correlation with accelerometer-measured vigorous PA (R = 0.124, p = 0.004). But the accelerometer-based number of steps was not showed correlation with walkability (R = 0.058, p = 0.184). Conclusions According to our results the built environment, especially walking and cycling places had significant but weak effect on physical activity patters. The participants were somewhat satisfied with walking and cycling possibilities of their built environment but this was not affected directly the time spent physically active. This study used first time the NEWS-Hungarian walkability scale to have a better understanding of the country specific details and compared them with PA level of the population further analysis needed.

2017. szeptember 23-án, az Európai Sporthét nyitónapján fontos szakpolitikai kezdeményezés született az Európai Unióban, amelynek célja az egészséges életmód előmozdítása. Az észt EU elnökség alatt Tartuban 3 uniós biztos aláírta az úgynevezett Tartui Felhívást az Egészséges Életmódért (Tartu Call for a Healthy Lifestyle). Navracsics Tibor, oktatásért, kultúráért, ifjúságért és sportért, Vytenis Andriukaitis, egészségügyért és élelmiszerbiztonságért és Phil Hogan, mezőgazdaságért és vidékfejlesztésért felelős uniós biztosok...