Background: Acne vulgaris is a chronic inflammatory disease of pilosebaceous unit, which has a variable course, with acute or insidious onset, relapses and recurrences. It is one of the commonest disease of patients attending the dermatology clinic. Tetracyclines are the most common oral antibiotic  prescribed for acne vulgaris. Aims: Our study aims to compare the efficacy of  topical 2.5% Benzoyl peroxide gel (BPO) with oral Doxycycline versus topical 2.5% Benzoyl peroxide gel with oral Lymecycline  in the treatment of acne vulgaris. Methods:  The study included 100 patients with acne vulgaris divided into two groups of 50 each. Group A were treated with topical 2.5% Benzoyl peroxide gel once daily application at night and capsule Doxycycline 100mg twice a day and Group B were treated with topical 2.5% Benzoyl Peroxide gel once daily application at night and capsule Lymecycline 408 mg once a day for 12 weeks.  The primary assessment was  done using Indian Association of Acne (IAA) grading at baseline and then every fortnight till 12 weeks. Patients were followed up for another 12 weeks after completion of the study. Results: The gradewise distribution of acne based upon IAA grading among both the groups were compared. Chi square test and p value for all 3 grades of acne at baseline, 2week, 4 week, 6 week, 8 week, 10 week, 12 week showed statistical improvement among patients in group B at 2, 8 and 10 weeks with p value being 0.01,0.01 and 0.007 respectively. Conclusions: From our study it is evident that  Lymecycline is superior to Doxycycline, with much statistical significance among moderate to severe acne.

<p class="abstract"><strong>Background:</strong> SLE is a systemic disease with multiorgan involvement occuring very rarely, if so, it has a very grave prognosis if not detected early. Our study enlightens about the evolution of mucocutaneous lesions which can serve as an eye opener for early detection of systemic involvement.</p><p class="abstract"><strong>Methods:</strong> A descriptive study was conducted in the Department of Dermatology at a tertiary care centre from May 2017 to April 2018 retrospectively. From 15 confirmed cases of SLE a critical retrospective analysis of symptom complex evolution was done and thus a clinical correlation of evolution of mucocutaneous lesions and systemic involvement was attempted.<strong></strong></p><p class="abstract"><strong>Results:</strong> Out of the fifteen patients in our study comprising various age groups (4-51 years), mean age group was 29.76 years. 14 (93%) were female patients and 1 (6.6%) male patient. Oral ulcerations, Non-scarring alopecia and vasculitic lesions were predominant (3 patients-80%) followed by photosensitivity and cheilitis (9 patients- 60%). Systemic involvement was present in 9 (60%), out of which one (6%) patient had lupus nephritis and 3 patients (20%) had CNS lupus, 2 (13%) had chronic unilateral scleritis, 2 (13%) had interstitial lung disease, one (6%) had coronary heart disease. Mucocutaneous lesions preceded the systemic involvement in 88.8% of cases, with mean duration being 3 years (4 months – 10 years).</p><p class="abstract"><strong>Conclusions:</strong> Mucocutaneous lesions could serve as an eye opener for diagnosis of SLE, which is always a diagnosis made out of high degree of suspicion apart from certain mucocutaneous lesions serving as an ominous sign of system involvement in SLE.</p><p class="abstract"> </p>