We present a case of bacteremia by an unsual, instrinsically multidrug resistant organism, Chryseobacterium indologenes in a 59 year old gentleman with squamous cell carcinoma of lung with multiple metastasis. Despite of treating as per sensitivity report after isolating Chryseobacterium indologenes , patient could not be survived. The pathogenicity and predictability of the organism towards antibiotics, both in vivo and in vitro needs further research. How to cite this article Bhagawati G, Bhardwaj A et al . Bacteremia by Chryseobacterium Indologenes in a Patient with Lung Cancer: A Clinical and Microbiological Investigation. Indian J Crit Care Med 2019;23(3):157-159.