The calcium ion (Ca2+) is a ubiquitous second messenger involved in key biological processes in prokaryotes and eukaryotes. In Plasmodium species, Ca2+ signaling plays a central role in the parasite life cycle. It has been associated with parasite development, fertilization, locomotion, and host cell infection. Despite the lack of a canonical inositol-1,4,5-triphosphate receptor gene in the Plasmodium genome, pharmacological evidence indicates that inositol-1,4,5-triphosphate triggers Ca2+ mobilization from the endoplasmic reticulum. Other structures such as acidocalcisomes, food vacuole and mitochondria are proposed to act as supplementary intracellular Ca2+ reservoirs. Several Ca2+-binding proteins (CaBPs) trigger downstream signaling. Other proteins with no EF-hand motifs, but apparently involved with CaBPs, are depicted as playing an important role in the erythrocyte invasion and egress. It is also proposed that a cross-talk among kinases, which are not members of the family of Ca2+-dependent protein kinases, such as protein kinases G, A and B, play additional roles mediated indirectly by Ca2+ regulation. This statement may be extended for proteins directly related to invasion or egress, such as SUB1, ERC, IMC1I, IMC1g, GAP45 and EBA175. In this review, we update our understanding of aspects of Ca2+-mediated signaling correlated to the developmental stages of the malaria parasite life cycle.

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Avaliação da cadeia produtiva madeiro-moveleiro no Distrito Federal utilizando a análise de fluxo de substância RESUMO No diagnóstico da cadeia madeiro-moveleiro no Distrito Federal observou-se a origem da matériaprima, a linha de produção, principais insumos, destino final dos produtos e resíduos gerados. Na elaboração do diagnóstico, utilizou-se a ferramenta "análise de fluxo de substância", que separou a madeira processada na forma serrada e em painéis reconstituídos, e seus resíduos (serragem e aparas) a substância avaliada. Os dados primários coletados em 43 empresas, localizadas no Distrito Federal, foram processados e analisados pelo programa "Programa 5 menos que são mais -redução de desperdício" do Sebrae -DF. Duas linhas de produção foram identificadas, uma constituída por madeireiras que fornecem a madeira serrada, e marcenarias produtoras de portais e janelas para construção civil. A outra foi o pólo moveleiro em desenvolvimento no Distrito Federal. A primeira foi responsável pela maior parte dos resíduos gerados em função do volume de substância madeira utilizada, emprego de maquinários antigos e a qualificação da mão-de-obra. A segunda linha produziu menor quantidade de resíduo devido à otimização da produção, gerando a melhoria no rendimento associada a ganhos no comportamento ambiental da cadeia como um todo. Palavras-chave: ecologia industrial, processamento de madeira, gestão ambientalEvaluation of the chain of production of the wood products sector in the Federal District using substance flow analysis ABSTRACT A diagnosis is made of the chain of production of the wood products sector in the Federal District, including the origin of the raw material, existing lines of production, main inputs, final destination of the products, main types of residues, and residue disposal. The Substance Flow Analysis tool was used in the diagnosis, where the substance evaluated was lumber, divided into composition boards and residues (fine and and coarse residues). The primary data were collected in 43 companies located in the Federal District and subsequently processed and analyzed using the Sebrae -DF software "Five Less which are More". Two distinct lines of production were identified: firstly, the sawmills that supply lumber and carpentry workshops that produce doors and windows for the civil construction industry; and secondly, the cabinetmaking hub being established in the Federal District. Most residues came from the first line of production because of the large volume of sawlogs processed, outmoded machinery used and low levels of skill of the workers. The second line of production had less waste, as a result of the optimization of production through productivity improvements associated with gains in the environmental behavior of the production chain as a whole.

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