The TGlittre-P proved to be a valid and reliable assessment of the functional capacity of healthy children aged 6 to 14 years.

BACKGROUND:The impulse oscillometry system is a noninvasive method of evaluating respiratory mechanics that is being increasingly used in the pediatric population. To date, no reference equations have been developed for healthy Brazilian children and adolescents. The purpose of the study was to determine the reference equations for impulse oscillometry system parameters in healthy children and adolescents. METHODS: We undertook an observational cross-sectional analytical study with healthy students age 6 -14 y from educational institutions in the Greater Florianópolis area. Biometric data were evaluated (weight, height, body mass index, and body surface area) as predictors and for sample characterization. All participants were submitted to evaluation of respiratory mechanics using an oscillometry system following American Thoracic Society standards. Three tests were recorded, with data acquisition for >20 s. For data normality verification, the Kolmogorov-Smirnov test was applied, and Pearson's correlation test identified the relationship between the predicted values of height, age, and weight and the oscillometric variables of resistance at 5 and 20 Hz reactance; respiratory impedance at 5 Hz resonant frequency; and reactance area. Models were developed using simple linear regression and multiple analyses. RESULTS: After the recruitment of 864 children, 123 subjects with an average age of 10.0 ؎ 2.4 y for boys and 9.9 ؎ 2.4 y for girls (P ‫؍‬ .94) were considered for final analysis. Correlations were identified between the dependent and predictor oscillometric variables, with height identified as having the greatest predictive power in the equations developed for boys in all oscillometric parameters, with a mean adjusted R 2 of 46.51%. Age had greater influence on resonant frequency (adjusted R 2 ‫؍‬ 40.1%) and reactance area (adjusted R 2 ‫؍‬ 48.8%) for girls. CONCLUSIONS: Reference equations were developed for males and females, and height was the most influential predictor variable for most impulse oscillometry system parameters in the population studied.

The CERN-MEDICIS (MEDical Isotopes Collected from ISolde) facility has delivered its first radioactive ion beam at CERN (Switzerland) in December 2017 to support the research and development in nuclear medicine using non-conventional radionuclides. Since then, fourteen institutes, including CERN, have joined the collaboration to drive the scientific program of this unique installation and evaluate the needs of the community to improve the research in imaging, diagnostics, radiation therapy and personalized medicine. The facility has been built as an extension of the ISOLDE (Isotope Separator On Line DEvice) facility at CERN. Handling of open radioisotope sources is made possible thanks to its Radiological Controlled Area and laboratory. Targets are being irradiated by the 1.4 GeV proton beam delivered by the CERN Proton Synchrotron Booster (PSB) on a station placed between the High Resolution Separator (HRS) ISOLDE target station and its beam dump. Irradiated target materials are also received from external institutes to undergo mass separation at CERN-MEDICIS. All targets are handled via a remote handling system and exploited on a dedicated isotope separator beamline. To allow for the release and collection of a specific radionuclide of medical interest, each target is heated to temperatures of up to 2,300°C. The created ions are extracted and accelerated to an energy up to 60 kV, and the beam steered through an off-line sector field magnet mass separator. This is followed by the extraction of the radionuclide of interest through mass separation and its subsequent implantation into a collection foil. In addition, the MELISSA (MEDICIS Laser Ion Source Setup At CERN) laser laboratory, in service since April 2019, helps to increase the separation efficiency and the selectivity. After collection, the implanted radionuclides are dispatched to the biomedical research centers, participating in the CERN-MEDICIS collaboration, for Research & Development in imaging or treatment. Since its commissioning, the CERN-MEDICIS facility has provided its partner institutes with non-conventional medical radionuclides such as Tb-149, Tb-152, Tb-155, Sm-153, Tm-165, Tm-167, Er-169, Yb-175, and Ac-225 with a high specific activity. This article provides a review of the achievements and milestones of CERN-MEDICIS since it has produced its first radioactive isotope in December 2017, with a special focus on its most recent operation in 2020.

Percepção de esforço e dispneia em crianças.

OBJETIVOS: verificar os efeitos de técnicas de fisioterapia respiratória (TFR) na dor e na função cardiorrespiratória de recém-nascidos (RN) clinicamente estáveis com prescrição de TFR, internados em unidade de terapia intensiva neonatal. MÉTODOS: ensaio clínico randomizado cego. Os RN foram alocados em três grupos: G1-controle; G2- fisioterapia convencional; G3-reequilíbrio tóracoabdominal. Neonatos do G2 e G3 receberam intervenção em atendimento único. Todos foram avaliados antes, imediatamente após e 15 minutos após o término da intervenção/repouso quanto aos parâmetros cardiorrespiratórios (saturação periférica de oxigênio/SpO2, frequências cardíaca/fc e respiratória/fr) e dor (escalas específicas: NIPS, NFCS e PIPP). Para análise dos dados foram aplicados: testes qui-quadrado, Friedman, Kruskal- Wallis e, posteriormente, análise de comparações múltiplas, com p<0,05 significativo. RESULTADOS: participaram do estudo 60 RN, dos quais 56,7% eram do sexo feminino, 68,3% prétermo/ muito baixo peso, com média de idade gestacional corrigida de 38,88 ± 2,03 semanas, idade de 13,22 ± 7,37 dias e peso de 1603,42 ± 439,16 gramas. Antes da intervenção, os grupos eram equivalentes quanto à presença de dor e parâmetros cardiorrespiratórios basais. Comparando os efeitos de cada um dos procedimentos, entre os grupos e no decorrer das três avaliações, não houve alterações significativas em nenhum dos parâmetros cardiorrespiratórios avaliados (p>0,05) e em relação à dor houve mudanças significativas nas escalas NIPS (G1 e G2, p=0,037 e p=0,011, respectivamente) e PIPP (G2, p=0,005). CONCLUSÕES: técnicas de fisioterapia respiratória não desencadearam dor, nem instabilidade cardiorrespiratória nos RN estudados.