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Aromatic Compounds Produced by Periconia atropurpurea, an Endophytic Fungus Associated with Xylopia aromatica. -The new compounds (I) and (II) are isolated from the ethyl acetate extract. Biological analyses are performed using two mammalian cell lines. Whereas (I) has no effect, compound (II) induces a slight increase in cell proliferation of HeLa and CHO cell lines and shows also a potent antifungal activity. -(TELES, H. L.; SORDI, R.; SILVA, G. H.; CASTRO-GAMBOA, I.; BOLZANI, V. D. S.; PFENNING, L. H.; MAGALHAES DE ABREU, L.; COSTA-NETO, C. M.; YOUNG, M. C. M.; ARAUJO*, A. R.; Phytochemistry 67 (2006) 24, 2686-2690; Inst. Quim., Univ. Estadual Paulista, 14800 Araraquara, Sao Paulo, Brazil; Eng.) -M. Bohle 16-206

Our purpose was to determine the anti-Mycobacterium tuberculosis activity of the metabolites produced by the endophitic fungus Phomopsis stipata (Lib.) B. Sutton, (Diaporthaceae), cultivated in different media.The antimycobacterial activity was assessed through the Resazurin Microtiter Assay (REMA) and the cytotoxicity test performed on macrophage cell line. The extracts derived from fungi grown on Corn Medium and Potato Dextrose Broth presented the smallest values of Minimum Inhibitory Concentration (MIC) and low cytotoxicity, which implies a high selectivity index. This is the first report on the chemical composition and antitubercular activity of metabolites of P. stipata, as well as the influence of culture medium on these properties.