We conclude that the prototype vaccine is safe and confers protection from infection without accelerating diabetes development in mice. These results encourage the development of a multivalent enterovirus vaccine for human use, which could be used to determine whether enterovirus infections trigger beta cell autoimmunity and type 1 diabetes in humans.

SummaryHepatitis is a common and potentially fatal manifestation of severe Coxsackievirus infections, particularly in newborn children.

Acute respiratory virus infections often have a prolonged duration in cystic fibrosis patients and predispose the cystic fibrosis lung to bacterial colonization. An experimental enterovirus infection model couples the ΔF508-mutation in CFTR to delayed virus clearance and defective antiviral immunity.

No abstract