Electosynthesis of N‐Substituted DL‐Arylglycineesters and 1,2‐Diarylamino‐1,2‐diarylethanes by Cathodic Reduction of Azomethines in the Presence of Carbon Dioxide The electroreduction of the N‐arylidene‐arylamines 1–12 in CO2‐saturated solvents of low proton availability as DMF at markedly more positive potentials than carbon dioxide end up in carboxylating the C‐atom and hydrogenating the nitrogen of the double bond. The resulting N‐arylsubstituted DL‐arylglycines and traces of carbamates may be isolated as esters, adding ethylchloride during the electrolysis. A competing pathway of the electrocarboxylation is the CC‐hydrodimerisation and the hydrogenation of the double bond, whose importance increases with the water content of the solvent. Based on cyclic‐voltametric evidence and product analysis the mechanism of the reductive electrocarboxylation reaction is discussed in terms of nucleophilic attack of the azomethine anion radical on a proton or CO2.

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Hauptreaktion bei der Elektroreduktion der N‐Ary1iden‐Aniline (I) in trockenem, CO2‐gesättigtem DMF in Gegenwart von Ethylchlorid ist die C‐Hydrocarboxylierung unter Bildung der Ester (II).

Due to the oxidation-sensitive cysteine groups in spikes and proteases, reactions with ozone occur which make it difficult for the spikes to enter the cell and for the protease to be activated. There are 3 key positions where ozone therapy becomes effective: • Virus spikes • ACE2 cell receptor and Nrf2 (Nuclear Factor 2) • Nf?B (Nuclear Factor Kappa B) The earlier ozone is used the lower the viral load will be. Other supporting effects of ozone therapy: • Hypocoagulation • Activation and modulation of the immune system • Prevention and treatment of bacterial superinfections • Increasing the depleted antioxidant potential • Increase of blood circulation and oxygen supply • Analgesia in case of muscle pain or joint pain • Increase of serotonin, helpful against depressions • Application as a “dead vaccine” Ozone is a very important part of the therapy of SARS-Cov-2, but we should never forget of the necessary orthomolecular supplement, only in combination the maximum effect can be achieved.

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