Background: Fibromyalgia (FM) is a syndrome characterized by widespread chronic pain associated to other symptoms, such as: fatigue, anxiety, depression and sleep disorders. Health education programs (HEP) have emerged as good non-pharmacological strategies to treat it. However, it is still not clear if the benefits are only subjective, or it has also objective impacts on immune and or neuroendocrine systems. Methods: Fifty-eight fibromyalgia women were randomly allocated in experimental group (n = 27) or control group (n = 31). The experimental group was submitted to HEP treatment for 11 weeks, while control group did not receive intervention at the same period. All data were collected at zero and 11th week by a blinded researcher. The statistical analysis were made in GraphPad Prism software (version 5.0) with significant level adjusted for α = 0.05. Results: Forty-four patients concluded the full study, 21 in the experimental group and 23 in the control group. Intragroup and intergroup analysis revealed that treatment induced significant increases of IL-4 plasma levels, antiinflammatory cytokine/inflammatory cytokine ratio (AC/IC ratio), salivary cortisol levels, in addition to significant decreases on FIQ scores. Intergroup variation analyses revealed also significant increases of IL-10 plasma levels. Conclusion: The results presented suggest that this kind of HEP could induce subjective and objective changes (immune and neuroendocrine), that could explain, at least in part the improvement of fibromyalgia patient's health status. (Clinical Trial Registration Number-ReBEC-RBR-5tdnbr).

We provide new records of the recently described frog Physalaemus feioi in the state of Minas Gerais, southeastern Brazil. Records presented here extend the distribution of P. feioi around 113 km straight north from Parque Estadual da Serra do Brigadeiro, the previously northernmost known record for the species.

Herein we provide new records of the leaf litter frogs Ischnocnema verrucosa and I. surda for the state of Minas Gerais, Southeast of Brazil. Our records fill the current gap in the geographic distribution of I. verrucosa in the east of Minas Gerais, and extend the distribution of I. surda in about 117 km straight southeast of its type locality. We also provide discussions regarding diagnose characters of I. surda.