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Introduction: The growing frequency of infections due to extended spectrum β-lactamase (ESBL) enzymes is a global dilemma, and the existence of ESBLs fluctuates between countries. Objective: To explored the occurrence of ESBLs producer E.coli in faecal carriage of humans, antimicrobial susceptibility profile and their viable threat factors. Method: For study 40 faecal samples were evaluated for antibiotic susceptibility profile and ESBLs production of all enterobacterial E. coli was phenotypically tested by the CLSI recommended methods. Result: ESBL E. coli was prevalent among all E. coli isolates and its frequency was recorded to be 72.9%. Current study revealed that ESBL producers E. coli or non ESBL producers E. coli both are highly susceptible to carbapenems and aminoglycosides class of antibiotics. Cefuroxime, cefaclor, and cefotaxime show high rate of resistivity followed by ampicillin, piperacillin, amoxicillin/clavulanic and amoxicillin/sulbactam in ESBLs as well as non ESBLs producers E. coli. Conclusion: Higher antimicrobial resistivity was shown by ESBL producers E. coli than non ESBL producers E.coli.