In 2020, there were more than 1.2 million new skin cancer diagnoses, and melanoma was the most recurrent type of cancer. On the other hand, melanoma is the least common but most serious form of skin cancer affecting both men and women. This work aims to assemble classification models to detect a case of melanoma with high accuracy based on a Convolutional Neural Networks system. The methodology considers training 21 models for image classification, with the best assembly performance of  EfficientNet and VGG-19 architectures,  the data augmentation technique was used to the images to improve its performance. The results show 92.85% of accuracy, 71.50% of sensitivity, and 94.89% of specificity, with an improvement of 0.06% in accuracy and specificity. The assembly of the classification models achieved higher accuracy in melanoma skin cancer image classification.