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A highly sensitive fluorescent carbon quantum dots (CDs) was designed to measure the interaction of antidepressant drugs and serum albumins (SA). In present investigation the interaction of bovine serum albumin (BSA) and human serum albumin (HSA) with antidepressant drugs viz. amitryptiline hydrochloride (AMT), chlorpromazine hydrochloride (CPZ) and desipramine hydrochloride (DSP) bioconjugated on CDs have been studied by different spectroscopic techniques i.e., Fluorescence, UV-Visible, Dynamic light scattering (DLS) and FT-IR. The CDs were prepared by one-pot method using glucose and PEG-200. The developed CDs showed blue luminescence under irradiation with ultra-violet. The Stern-Volmer quenching constant (K sv ) indicates the presence of static quenching mechanism. The apparent binding constant K a between antidepressant drugs with complex of SA-CDs have been determined. These results illustrated that CPZ shows strong binding with HSA. As further analyzed by FT-IR spectroscopy and DLS technique, the results suggested induced conformational changes on SA, thus confirming the experimental and theoretical results. Thus, a thorough knowledge of the energetics of drug-protein affinities in presence of CDs as attempted in this work is vital in giving way for appropriate drug delivery.

The excellent biocompatible and monodispersed gold nanoparticles (AuNPs) functionalized by amino based ionic liquid (IL) have been synthesized for the demonstration of their interaction with human serum albumin (HSA).

Background : Safe drinking water and basic sanitation is of crucial importance to the prevention of human heath1. Water can become a vehicle for transmission of feco oral group of infections, because the fecal contamination of water is common and its avoidance and subsequent purification is vigilant2. One of the goal of MDG states - Halve, by 2015, the proportion of people without sustainable access 3 to an improved water source and sanitation3. Materials and methodology : A descriptive study was undertaken among 300 samples, in adopted villages of MCON Manipal, Udupi District using structured questionnaire. SPSS 16.0 software was used for data analysis. Results : Findings of the study showed that 42% had average knowledge and majority (75 %) of the subjects followed unsafe practices on water, sanitation and hygiene. Majority (88 %) of the subjects performed unskilled hand washing. Conclusion: Water pollution is a growing hazard in many developing countries due to human activity. Water is an essential factor in the economic, social and cultural development of community. It can eliminate diseases, and improve quality of life