The present study was designed to evaluate the relationship between serum leptin and sex hormones in obese infertile men and women. Sex hormones (LH, FSH and testosterone) and serum leptin of infertile obese men (n=66) and women (n=30) compared with control fertile men (n=60) and women (n=30) with same ages to find the relation and contribution of serum leptin and sex hormones in causation of fertility or infertility. The results revealed that Serum leptin level in obese (BMI>240 fertile and infertile male and female were significantly (p<0.01) higher than normal (BMI<24) fertile male but in infertile normal subjects it was significantly decreased. Values of LH, FSH and Testosterone were significantly (p<0.01) higher in obese (BMI<24) fertile and infertile men and women than normal (BMI<24) subjects. Serum leptin has strong negative correlation with LH, FSH and testosterone in fertile obese and normal male and female which were statistically significant at the level of p<0.05. This study has concluded that hyperleptinemia is associated with infertility in men and women. Sex hormonal imbalance may also be associated with BMI and serum leptin in infertility.

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